State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, SAR, China.
Oxid Med Cell Longev. 2022 Aug 29;2022:6439097. doi: 10.1155/2022/6439097. eCollection 2022.
Epigenetic regulation of gene expression, including DNA methylation and histone modifications, provides finely tuned responses for cells that undergo cellular environment changes. Abundant evidences have demonstrated the detrimental role of oxidative stress in various human pathogenesis since oxidative stress results from the imbalance between reactive oxygen species (ROS) accumulation and antioxidant defense system. Stem cells can self-renew themselves and meanwhile have the potential to differentiate into many other cell types. As some studies have described the effects of oxidative stress on homeostasis and cell fate decision of stem cells, epigenetic alterations have emerged crucial for mediating the stem cell behaviours under oxidative stress. Here, we review recent findings on the oxidative effects on DNA and histone modifications in stem cells. We propose that epigenetic alterations and oxidative stress may influence each other in stem cells.
基因表达的表观遗传调控，包括 DNA 甲基化和组蛋白修饰，为细胞提供了精细的响应，使细胞能够适应细胞环境的变化。大量证据表明，氧化应激在各种人类疾病发病机制中起着有害作用，因为氧化应激是由活性氧（ROS）积累和抗氧化防御系统之间的失衡引起的。干细胞可以自我更新，同时具有分化为多种其他细胞类型的潜能。正如一些研究描述的那样，氧化应激对干细胞的内稳态和细胞命运决定有影响，表观遗传改变对于介导干细胞在氧化应激下的行为至关重要。在这里，我们综述了最近关于氧化应激对干细胞中 DNA 和组蛋白修饰的影响的研究结果。我们提出，在干细胞中，表观遗传改变和氧化应激可能相互影响。
