自我报告的药物依从性作为依从性促进干预临床试验结果的有效性：MACH14研究的结果
The validity of self-reported medication adherence as an outcome in clinical trials of adherence-promotion interventions: Findings from the MACH14 study.
作者信息
Simoni Jane M, Huh David, Wang Yan, Wilson Ira B, Reynolds Nancy R, Remien Robert H, Goggin Kathy, Gross Robert, Rosen Marc I, Schneiderman Neil, Arnsten Julia, Golin Carol E, Erlen Judith A, Bangsberg David R, Liu Honghu
机构信息
Department of Psychology, University of Washington, Box 351525, Seattle, WA, 98195, USA,
出版信息
AIDS Behav. 2014 Dec;18(12):2285-90. doi: 10.1007/s10461-014-0905-x.
Abstract
In medication adherence-promotion trials, participants in the intervention arm are often cognizant of the researcher's aim to improve adherence; this may lead to their inflating reports of their own adherence compared to control arm participants. Using data from 1,247 HIV-positive participants across eight U.S. Studies in the Multi-site Adherence Collaboration on HIV (MACH14) collaboration, we evaluated the validity of self-reported adherence by examining whether its association with two more objective outcomes [1], electronically monitored adherence and [2] viral load, varied by study arm. After adjusting for potential confounders, there was no evidence of greater overestimation of self-reported adherence among intervention arm participants, supporting its potential as a trial outcome indicator.
摘要
在促进药物依从性的试验中，干预组的参与者通常知晓研究人员旨在提高依从性的目的；与对照组参与者相比，这可能导致他们夸大自己的依从性报告。利用来自美国八项关于HIV的多中心依从性协作研究（MACH14）中1247名HIV阳性参与者的数据，我们通过检查自我报告的依从性与另外两个更客观的结果[1]电子监测的依从性和[2]病毒载量之间的关联是否因研究组而异，来评估自我报告依从性的有效性。在对潜在混杂因素进行调整后，没有证据表明干预组参与者对自我报告依从性的高估更严重，这支持了其作为试验结果指标的潜力。
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