Department of Integrative Medical Biology, Umeå University, S-901 87, Umea, Sweden.
Department of Public Health and Clinical Medicine, Umeå University, S-901 87, Umea, Sweden.
Eur J Clin Pharmacol. 2022 May;78(5):869-877. doi: 10.1007/s00228-022-03284-4. Epub 2022 Feb 14.
To describe and compare self-reported medication adherence assessed with the 5-item version of Medication Adherence Report Scale (MARS-5) and pharmacy refill adherence based on data from the Swedish Prescribed Drug Register (SPDR) among persons with ischemic stroke, and to investigate independent predictors associated with respective assessments.
A study questionnaire was sent to persons with ischemic stroke registered in the Swedish Stroke Register between Dec 2011 and March 2012, and who lived at home 3 months after discharge. The primary outcome was dichotomized to adherent/non-adherent based on MARS-5 and SPDR and analyzed with multivariable logistic regression. Adherence according to MARS-5 was defined as score 23 or higher (out of 25). Adherence according to SPDR was defined as at least one filled statin prescription recorded in SPDR in each 6-month interval during 2 years of follow-up.
Of 420 participants, 367 (87%) and 329 (78%) were adherent according to MARS-5 and SPDR, respectively, and 294 (70%) participants were adherent according to both assessments. A significant association was shown between medication adherence according to the two assessments (p = 0.020). Independent predictors associated with medication adherence according to MARS-5 were female sex, while factors associated with SPDR were male sex and being younger.
The majority of participants were classified as adherent, 87% according to MARS-5 and 78% based on data from SPDR. However, only 70% were adherent according to both MARS-5 and SPDR, and different predictors were associated with the different measurements, suggesting that these assessments are measuring different aspects of adherence.
描述并比较缺血性脑卒中患者自我报告的药物依从性，采用药物依从性报告量表（MARS-5）的 5 项版本进行评估，以及基于瑞典处方药物登记（SPDR）的药物补充依从性，并调查与各自评估相关的独立预测因素。
向 2011 年 12 月至 2012 年 3 月期间在瑞典中风登记处登记且出院后 3 个月居住在家中的缺血性中风患者发送研究问卷。主要结局根据 MARS-5 和 SPDR 分为依从/不依从，并使用多变量逻辑回归进行分析。根据 MARS-5 的依从性定义为得分 23 或更高（满分 25 分）。根据 SPDR 的依从性定义为在 2 年随访期间，每 6 个月间隔在 SPDR 中至少有一次记录的他汀类药物处方。
在 420 名参与者中，分别有 367 名（87%）和 329 名（78%）根据 MARS-5 和 SPDR 被归类为依从者，294 名（70%）参与者根据两种评估方法均为依从者。两种评估方法之间的药物依从性呈显著相关（p=0.020）。与 MARS-5 药物依从性相关的独立预测因素是女性，而与 SPDR 相关的因素是男性和年龄较小。
大多数参与者被归类为依从者，根据 MARS-5 为 87%，根据 SPDR 为 78%。然而，根据 MARS-5 和 SPDR 两者均为依从者仅占 70%，且不同的评估方法与不同的预测因素相关，表明这些评估方法测量的是药物依从性的不同方面。
