Pesonen E, Sherman F, Breuer J, Simpson I, Elias W, Sahn D J, Andersson S, Tikkanen I, Fyhrquist F, Reichman R
Department of Pediatrics, University Central Hospital, Helsinki, Finland.
Life Sci. 1989;45(6):553-8. doi: 10.1016/0024-3205(89)90106-9.
The design of the study was to determine whether an increased blood flow as seen in shunt lesions could serve as a stimulus for the secretion of atrial natriuretic factor (ANF). Since atrial pressure, flow, and dilatation are closely related, an experimental ductus arteriosus model was utilized, in which acute changes of flow are assumed not to dilate the left atrium. In six dogs, a Dacron graft was constructed between the main pulmonary artery and the innominate artery. Constricting and releasing the tape around the graft adjusted the amount of "ductal" shunting. The total pulmonary flow and the shunt flow were measured by electromagnetic-flow transducers around the aortic root and around the graft. Plasma ANF concentration was measured from both cardiac atria. The size of the left atrium was determined from echocardiographic measurements made from a short-axis view. The total pulmonary flow varied between 1.2 and 5.8 1/min. The highest measured ANF was 396 pg/ml, and this was from the left atrium when the pressure was 18 mmHg, the highest left atrial pressure recorded. The highest right atrial pressure (5 mmHg) also correlated with the highest right-atrial level of ANF (366 pg/ml). The right atrial pressure had a significant correlation with plasma ANF concentration (R = 0.43, p less than 0.05). Pulmonary flow and plasma ANF concentration did not correlate; neither did left atrial size and ANF levels in 16 flow states where the size was measured. In the absence of atrial dilatation there was minimal stimulus for ANF secretion. A transient increase of left atrial pressure, without a concomitant significant atrial dilatation, did not serve as a significant stimulus for ANF secretion.
本研究的设计目的是确定分流性病变中所观察到的血流量增加是否可作为心房利钠因子（ANF）分泌的刺激因素。由于心房压力、血流量和扩张密切相关，因此采用了一种实验性动脉导管模型，在该模型中，假定血流量的急性变化不会使左心房扩张。对6只犬，在主肺动脉和无名动脉之间构建了涤纶移植物。通过收紧和松开移植物周围的束带调节“导管”分流的量。通过主动脉根部周围和移植物周围的电磁流量传感器测量总肺血流量和分流血流量。从两个心脏心房测量血浆ANF浓度。左心房大小通过短轴视图的超声心动图测量来确定。总肺血流量在1.2至5.8升/分钟之间变化。测得的最高ANF为396皮克/毫升，这是在压力为18毫米汞柱（记录到的最高左心房压力）时左心房的测量值。最高右心房压力（5毫米汞柱）也与最高右心房ANF水平（366皮克/毫升）相关。右心房压力与血浆ANF浓度显著相关（R = 0.43，p < 0.05）。肺血流量与血浆ANF浓度不相关；在测量了大小的16种血流状态下，左心房大小与ANF水平也不相关。在没有心房扩张的情况下，ANF分泌的刺激最小。左心房压力的短暂升高，若没有伴随显著的心房扩张，不会作为ANF分泌的显著刺激因素。
