肥胖、代谢综合征与气道疾病：一个生物能量问题？
Obesity, metabolic syndrome, and airway disease: a bioenergetic problem?
作者信息
Agrawal Anurag, Prakash Y S
机构信息
Molecular Immunogenetics Laboratory and Centre of Excellence for Translational Research in Asthma & Lung Disease, CSIR-Institute of Genomics and Integrative Biology, Mall Road, Delhi 110007, India.
Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.
出版信息
Immunol Allergy Clin North Am. 2014 Nov;34(4):785-96. doi: 10.1016/j.iac.2014.07.004. Epub 2014 Aug 21.
Abstract
Multiple studies have determined that obesity increases asthma risk or severity. Metabolic changes of obesity, such as diabetes or insulin resistance, are associated with asthma and poorer lung function. Insulin resistance is also found to increase asthma risk independent of body mass. Conversely, asthma is associated with abnormal glucose and lipid metabolism, insulin resistance, and obesity. Here we review our current understanding of how dietary and lifestyle factors lead to changes in mitochondrial metabolism and cellular bioenergetics, inducing various components of the cardiometabolic syndrome and airway disease.
摘要
多项研究已确定肥胖会增加哮喘风险或加重哮喘病情。肥胖的代谢变化，如糖尿病或胰岛素抵抗，与哮喘及较差的肺功能相关。还发现胰岛素抵抗会独立于体重增加哮喘风险。相反，哮喘与葡萄糖和脂质代谢异常、胰岛素抵抗及肥胖有关。在此，我们综述了目前对于饮食和生活方式因素如何导致线粒体代谢和细胞生物能学变化，进而引发心脏代谢综合征和气道疾病各个组成部分的理解。
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