Hartsoe Paige, Holguin Fernando, Chu Hong Wei
Department of Medicine, National Jewish Health, Denver, CO 80222, USA.
Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Int J Mol Sci. 2024 Mar 3;25(5):2944. doi: 10.3390/ijms25052944.
Mitochondrial dysfunction and metabolic reprogramming have been extensively studied in many disorders ranging from cardiovascular to neurodegenerative disease. Obesity has previously been associated with mitochondrial fragmentation, dysregulated glycolysis, and oxidative phosphorylation, as well as increased reactive oxygen species production. Current treatments focus on reducing cellular stress to restore homeostasis through the use of antioxidants or alterations of mitochondrial dynamics. This review focuses on the role of mitochondrial dysfunction in obesity particularly for those suffering from asthma and examines mitochondrial transfer from mesenchymal stem cells to restore function as a potential therapy. Mitochondrial targeted therapy to restore healthy metabolism may provide a unique approach to alleviate dysregulation in individuals with this unique endotype.
线粒体功能障碍和代谢重编程已在从心血管疾病到神经退行性疾病等多种疾病中得到广泛研究。肥胖症此前一直与线粒体碎片化、糖酵解失调、氧化磷酸化以及活性氧生成增加有关。目前的治疗方法侧重于通过使用抗氧化剂或改变线粒体动力学来减轻细胞应激以恢复体内平衡。本综述重点关注线粒体功能障碍在肥胖症中的作用，特别是对于哮喘患者，并研究间充质干细胞的线粒体转移作为一种潜在治疗方法来恢复功能。旨在恢复健康代谢的线粒体靶向治疗可能为缓解这种独特内型个体的失调提供一种独特方法。
