Research Center of Modernization of Chinese Medicines, Central South University, Changsha, PR China.
J Sep Sci. 2010 Feb;33(3):410-21. doi: 10.1002/jssc.200900653.
Development of chromatographic fingerprint (CF) and related chemometric methods and their applications to quality control of traditional Chinese medicines (TCMs) were discussed. CF is essentially a kind of quality control method for TCMs (or Chinese herbal medicines). Also, it is a quality-relevant-data high-throughput and integral tool to explore chemically the complexity of TCMs. With the help of chemometrics, some difficulties in evaluation and analysis of CFs, such as calculation of information content, peak alignment, pattern analysis, deconvolution of overlapping peaks, etc. could be well solved. To further explore TCMs synergic quality, intensive study of CF coupled with chemometrics will create the possibility to achieve the aim to reveal the working mechanisms of TCMs and to further control and strengthen TCMs' intrinsic quality in a comprehensive manner.
讨论了色谱指纹图谱（CF）及其相关化学计量学方法的发展及其在中药（TCM）质量控制中的应用。CF 本质上是一种 TCM（或中草药）的质量控制方法。同时，它也是一种与质量相关的数据高通量和整体工具，可用于探索 TCM 的复杂性。借助化学计量学，可以很好地解决 CF 评价和分析中的一些困难，例如信息量的计算、峰对齐、模式分析、重叠峰的分解等。为了进一步探索 TCM 的协同质量，深入研究 CF 与化学计量学相结合将有可能实现揭示 TCM 作用机制并进一步全面控制和加强 TCM 内在质量的目标。
