Zhu Qiong-Ni, Lu Yuan-Fu, Shi Jing-Zhen, Wu Qin, Zhang Feng, Shi Jing-Shan, Liu Jie
Zhongguo Zhong Yao Za Zhi. 2014 May;39(10):1892-6.
To study the effect of Wansheng Huafeng Dan (WSHFD) and mercuric chloride on renal mercury (Hg) extraction transporters (Oat1, Oct2), renal mercury excretion transporters (Mrp4, Mate2K), renal mercury accumulation and kidney injury molecule-1 (Kim-1). The ancient prescription of WSHFD containing 10-fold Hg caused much lower renal mercury accumulation and renal toxicity than HgCl2 in rats, with less effect on renal transporters than HgCl2. The above indicators had no significant difference in WSHFDO, WSHFD2 and WSHFD3 groups, indicating no effect of WSHFD with reduced or no cinnabar.
研究万生华峰丹（WSHFD）与氯化汞对肾脏汞（Hg）摄取转运体（Oat1、Oct2）、肾脏汞排泄转运体（Mrp4、Mate2K）、肾脏汞蓄积及肾损伤分子-1（Kim-1）的影响。含10倍汞的WSHFD古方在大鼠中引起的肾脏汞蓄积和肾毒性远低于氯化汞，对肾脏转运体的影响也小于氯化汞。上述指标在WSHFDO、WSHFD2和WSHFD3组中无显著差异，表明不含或减少朱砂的WSHFD无此作用。
