Goilav C, Piot P
Department of Microbiology, Institute of Tropical Medicine, Antwerp, Belgium.
Am J Med. 1989 Sep 4;87(3A):21S-25S. doi: 10.1016/0002-9343(89)90526-3.
Homosexual men are at increased risk for infection with hepatitis B virus (HBV). Both plasma-derived and recombinant deoxyribonucleic acid vaccines have been shown to induce long-standing protective immunity in this population. However, non-responders and weak responders to HBV vaccine have recently become a problem among homosexual men because of an impaired antibody response due to previous infection with human immunodeficiency virus. In addition, human immunodeficiency virus infection predisposes persons to the development of a HBV carrier state following HBV infection. Vaccination still remains the most effective tool for preventing hepatitis B in homosexual men, although recent behavioral changes have apparently resulted in a decreased incidence of HBV infection among this group.
男同性恋者感染乙型肝炎病毒（HBV）的风险增加。血浆源性疫苗和重组脱氧核糖核酸疫苗均已证明可在该人群中诱导长期保护性免疫。然而，由于先前感染人类免疫缺陷病毒导致抗体反应受损，对HBV疫苗无应答者和弱应答者最近在男同性恋者中成为一个问题。此外，人类免疫缺陷病毒感染使个体在感染HBV后易发展为HBV携带者状态。尽管最近的行为变化显然导致该群体中HBV感染发病率下降，但接种疫苗仍然是预防男同性恋者感染乙型肝炎最有效的手段。
