感染HIV抗体的同性恋男性对血浆源性乙肝疫苗的反应性受损。
Impaired responsiveness of homosexual men with HIV antibodies to plasma derived hepatitis B vaccine.
作者信息
Carne C A, Weller I V, Waite J, Briggs M, Pearce F, Adler M W, Tedder R S
出版信息
Br Med J (Clin Res Ed). 1987 Apr 4;294(6576):866-8. doi: 10.1136/bmj.294.6576.866.
Abstract
Thirty five homosexual men (17 positive for antibody to the human immunodeficiency virus (HIV) and 18 consistently negative) were vaccinated against hepatitis B virus infection. Eight of the 17 seropositive patients failed to develop detectable hepatitis B surface antibody within three months of the third injection compared with only one of the 18 seronegative patients (p less than 0.01). HIV infection is prevalent in the developed world in groups at risk for hepatitis B infection and in certain Third World countries where widespread vaccination programmes exist. This study shows the impact that coincident HIV infection may have on an otherwise efficacious vaccine. The efficacy of this and other vaccines in patients infected with HIV needs to be studied urgently.
摘要
35名同性恋男性（17名人类免疫缺陷病毒（HIV）抗体呈阳性，18名持续呈阴性）接种了预防乙型肝炎病毒感染的疫苗。17名血清阳性患者中有8名在第三次注射后的三个月内未能产生可检测到的乙型肝炎表面抗体，而18名血清阴性患者中只有1名出现这种情况（p值小于0.01）。在乙型肝炎感染的高危人群以及存在广泛疫苗接种计划的某些第三世界国家，HIV感染在发达国家很普遍。这项研究表明，同时感染HIV可能会对一种原本有效的疫苗产生影响。迫切需要研究这种疫苗以及其他疫苗对HIV感染患者的疗效。
相似文献
1
Impaired responsiveness of homosexual men with HIV antibodies to plasma derived hepatitis B vaccine.
Br Med J (Clin Res Ed). 1987 Apr 4;294(6576):866-8. doi: 10.1136/bmj.294.6576.866.
2
Human immunodeficiency virus infection, hepatitis B virus infection, and sexual behaviour of women attending a genitourinary medicine clinic.
Br Med J (Clin Res Ed). 1988 Feb 13;296(6620):473-5. doi: 10.1136/bmj.296.6620.473.
3
Antibody to human immunodeficiency virus (HIV) and suboptimal response to hepatitis B vaccination.
Ann Intern Med. 1988 Jul 15;109(2):101-5. doi: 10.7326/0003-4819-109-2-101.
4
Outcome of hepatitis B virus infection in homosexual men and its relation to prior human immunodeficiency virus infection.
J Infect Dis. 1991 Mar;163(3):454-9. doi: 10.1093/infdis/163.3.454.
5
Vaccination against hepatitis B in homosexual men. A review.
Am J Med. 1989 Sep 4;87(3A):21S-25S. doi: 10.1016/0002-9343(89)90526-3.
6
Long-term immunogenicity and efficacy of hepatitis B vaccine in homosexual men.
N Engl J Med. 1986 Jul 24;315(4):209-14. doi: 10.1056/NEJM198607243150401.
7
Integration of hepatitis B vaccination into rural African primary health care programmes.
BMJ. 1991 Feb 9;302(6772):313-6. doi: 10.1136/bmj.302.6772.313.
8
Protective efficacy of a recombinant DNA vaccine against hepatitis B in male homosexuals: results at 36 months.
Vaccine. 1990 Mar;8 Suppl:S50-2; discussion S60-2. doi: 10.1016/0264-410x(90)90219-c.
9
Failure to deliver hepatitis B vaccine: confessions from a genitourinary medicine clinic.
BMJ. 1991 Jul 13;303(6794):97-101. doi: 10.1136/bmj.303.6794.97.
10
Response to hepatitis B vaccination in a primary care setting: influence of HIV infection, CD4+ lymphocyte count and vaccination schedule.
Int J STD AIDS. 1996 Nov-Dec;7(7):490-4. doi: 10.1258/0956462961918563.
引用本文的文献
1
Immunogenicity and safety of 4 vs. 3 standard doses of HBV vaccination in HIV-infected adults with isolated anti-HBc antibody.
AIDS Res Ther. 2019 May 3;16(1):10. doi: 10.1186/s12981-019-0225-3.
2
Hepatitis B vaccination for reducing morbidity and mortality in persons with HIV infection.
Cochrane Database Syst Rev. 2014 Oct 9;2014(10):CD009886. doi: 10.1002/14651858.CD009886.pub2.
3
Rapid loss of vaccine-acquired hepatitis B surface antibody after three doses of hepatitis B vaccination in HIV-infected persons.
Int J STD AIDS. 2014 Mar;25(3):201-6. doi: 10.1177/0956462413495820. Epub 2013 Aug 29.
4
Hepatitis B vaccination in HIV-infected youth: a randomized trial of three regimens.
J Acquir Immune Defic Syndr. 2011 Apr;56(4):325-32. doi: 10.1097/QAI.0b013e318203e9f2.
5
Randomized controlled trial of Hepatitis B virus vaccine in HIV-1-infected patients comparing two different doses.
AIDS Res Ther. 2006 Apr 6;3:9. doi: 10.1186/1742-6405-3-9.
6
Management of hepatitis B in patients coinfected with the human immunodeficiency virus.
Eur J Clin Microbiol Infect Dis. 2004 May;23(5):366-74. doi: 10.1007/s10096-004-1127-3. Epub 2004 Apr 27.
7
HIV infection and routine childhood immunization: a review.
Bull World Health Organ. 1987;65(6):905-11.
8
Immunological abnormalities in human immunodeficiency virus (HIV)-infected asymptomatic homosexual men. HIV affects the immune system before CD4+ T helper cell depletion occurs.
J Clin Invest. 1988 Dec;82(6):1908-14. doi: 10.1172/JCI113809.
9
Routine immunization of the HIV-positive asymptomatic patient.
J Gen Intern Med. 1990 Mar-Apr;5(2):147-52. doi: 10.1007/BF02600517.
10
Preventing secondary infections among HIV-positive persons.
Public Health Rep. 1991 Sep-Oct;106(5):503-17.
本文引用的文献
1
Immunogenic effect of inactivated hepatitis B vaccine: comparison of 20 microgram and 40 microgram doses.
J Med Virol. 1981;8(2):119-21. doi: 10.1002/jmv.1890080205.
2
A sensitive immunoradiometric assay for the detection of hepatitis B surface antigen.
J Virol Methods. 1980;1(6):311-23. doi: 10.1016/0166-0934(80)90048-8.
3
A controlled clinical trial of the efficacy of the hepatitis B vaccine (Heptavax B): a final report.
Hepatology. 1981 Sep-Oct;1(5):377-85. doi: 10.1002/hep.1840010502.
4
Contrasting patterns and frequency of antibodies to the surface, core, and e antigens of hepatitis B virus in blood donors and in homosexual patients.
J Med Virol. 1981;6(4):323-32. doi: 10.1002/jmv.1890060407.
5
Indications for use of hepatitis B vaccine, based on cost-effectiveness analysis.
N Engl J Med. 1982 Sep 9;307(11):644-52. doi: 10.1056/NEJM198209093071103.
6
Should homosexuals be vaccinated against hepatitis B virus? Cost and benefit assessment.
Br Med J (Clin Res Ed). 1983 May 21;286(6378):1621-4. doi: 10.1136/bmj.286.6378.1621.
7
Efficacy of a heat inactivated hepatitis B vaccine in male homosexuals: outcome of a placebo controlled double blind trial.
Br Med J (Clin Res Ed). 1983 Apr 23;286(6374):1305-8. doi: 10.1136/bmj.286.6374.1305.
8
Hepatitis B vaccine in dialysis patients.
N Engl J Med. 1984 Dec 6;311(23):1515-6. doi: 10.1056/NEJM198412063112313.
9
Abnormalities of B-cell activation and immunoregulation in patients with the acquired immunodeficiency syndrome.
N Engl J Med. 1983 Aug 25;309(8):453-8. doi: 10.1056/NEJM198308253090803.
10
Efficacy of heat-inactivated hepatitis B vaccine in haemodialysis patients and staff. Double-blind placebo-controlled trial.
Lancet. 1983 Dec 10;2(8363):1323-8. doi: 10.1016/s0140-6736(83)91089-9.
Zotero 插件