Carne C A, Weller I V, Waite J, Briggs M, Pearce F, Adler M W, Tedder R S
Br Med J (Clin Res Ed). 1987 Apr 4;294(6576):866-8. doi: 10.1136/bmj.294.6576.866.
Thirty five homosexual men (17 positive for antibody to the human immunodeficiency virus (HIV) and 18 consistently negative) were vaccinated against hepatitis B virus infection. Eight of the 17 seropositive patients failed to develop detectable hepatitis B surface antibody within three months of the third injection compared with only one of the 18 seronegative patients (p less than 0.01). HIV infection is prevalent in the developed world in groups at risk for hepatitis B infection and in certain Third World countries where widespread vaccination programmes exist. This study shows the impact that coincident HIV infection may have on an otherwise efficacious vaccine. The efficacy of this and other vaccines in patients infected with HIV needs to be studied urgently.
35名同性恋男性（17名人类免疫缺陷病毒（HIV）抗体呈阳性，18名持续呈阴性）接种了预防乙型肝炎病毒感染的疫苗。17名血清阳性患者中有8名在第三次注射后的三个月内未能产生可检测到的乙型肝炎表面抗体，而18名血清阴性患者中只有1名出现这种情况（p值小于0.01）。在乙型肝炎感染的高危人群以及存在广泛疫苗接种计划的某些第三世界国家，HIV感染在发达国家很普遍。这项研究表明，同时感染HIV可能会对一种原本有效的疫苗产生影响。迫切需要研究这种疫苗以及其他疫苗对HIV感染患者的疗效。
