Oei H H, Zoganas H C, McCord J M, Schaffer S W
Res Commun Chem Pathol Pharmacol. 1986 Feb;51(2):195-203.
Single doses of ethanol (5 g/kg, intragastric) produce oxidative stress in the liver as well as in the heart. The metabolism of acetaldehyde through xanthine oxidase appears to play an important role in the production of oxidative stress in the heart, but it has only a contributory role in the liver. It is suggested that, as oxidative stress through lipid peroxidation may produce organ pathology, the metabolic pathway of acetaldehyde through xanthine oxidase may be one of the mechanisms which mediate cardiac pathology in alcoholism.
单次给予乙醇（5克/千克，灌胃）会在肝脏和心脏中产生氧化应激。乙醛通过黄嘌呤氧化酶的代谢似乎在心脏氧化应激的产生中起重要作用，但在肝脏中仅起辅助作用。有人认为，由于脂质过氧化引起的氧化应激可能导致器官病变，乙醛通过黄嘌呤氧化酶的代谢途径可能是介导酒精中毒中心脏病变的机制之一。
