Louis Elan D, Michalec Monika
GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
J Neurol Sci. 2014 Dec 15;347(1-2):174-8. doi: 10.1016/j.jns.2014.09.042. Epub 2014 Sep 30.
The notion that there is an association between essential tremor (ET) and higher ethanol consumption has crept into the literature; however, the data are limited and conflicted. A total of 354 ET cases and 370 matched controls were enrolled in a clinical-epidemiological study. Average current daily ethanol consumption was estimated using the Willett Semi-quantitative Food Frequency Questionnaire. The proportion of cases and controls who drank any ethanol was similar: 66.7% vs. 64.1%, p=0.46, as was the proportion who reported heavy ethanol consumption: 4.0% vs. 3.5%, p=0.74. The average daily ethanol intake was numerically higher in cases than controls (7.99 ± 12.39 [median=3.03] vs. 6.55 ± 10.62 [median=1.80] g), but this difference did not reach significance (p=0.15). Among cases, there was no correlation between average daily ethanol intake and tremor severity (r=0.008, p=0.88). These data, on more than 700 enrollees, do not support any sizable differences between ET cases and controls in terms of average daily ethanol consumption or ethanol overuse. The absence of a correlation in cases between ethanol consumption and tremor severity goes against the hypothesis that ET patients are self-medicating to a significant degree.
原发性震颤（ET）与较高乙醇摄入量之间存在关联这一观点已悄然出现在文献中；然而，相关数据有限且相互矛盾。一项临床流行病学研究纳入了354例ET患者和370例匹配的对照。使用威尔特半定量食物频率问卷估计当前每日乙醇平均摄入量。饮酒的患者和对照的比例相似：66.7%对64.1%，p = 0.46，报告大量饮酒的比例也相似：4.0%对3.5%，p = 0.74。患者的每日乙醇平均摄入量在数值上高于对照（7.99±12.39[中位数 = 3.03]对6.55±10.62[中位数 = 1.80]克），但这种差异未达到显著水平（p = 0.15）。在患者中，每日乙醇平均摄入量与震颤严重程度之间无相关性（r = 0.008，p = 0.88）。这些针对700多名受试者的数据并不支持ET患者与对照在每日乙醇平均摄入量或乙醇过度使用方面存在任何显著差异。患者中乙醇摄入量与震颤严重程度之间缺乏相关性，这与ET患者在很大程度上自我用药的假设相悖。
