• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

源自链格孢酚的天然间苯二酚内酯。

Natural resorcylic lactones derived from alternariol.

作者信息

Podlech Joachim

机构信息

Karlsruhe Institute of Technology (KIT), Institute of Organic Chemistry, Kaiserstraße 12, 76131 Karlsruhe, Germany.

出版信息

Beilstein J Org Chem. 2024 Aug 30;20:2171-2207. doi: 10.3762/bjoc.20.187. eCollection 2024.

DOI:10.3762/bjoc.20.187
PMID:39224229
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11368053/
Abstract

In this overview, naturally occurring resorcylic lactones biosynthetically derived from alternariol and almost exclusively produced by fungi, are discussed with view on their isolation, structure, biological activities, biosynthesis, and total syntheses. This class of compounds consists until now of 127 naturally occurring compounds, with very divers structural motifs. Although only a handful of these toxins (i.e., alternariol and its 9--methyl ether, altenusin, dehydroaltenusin, altertenuol, and altenuene) were frequently found and isolated as fungal contaminants in food and feed and have been investigated in significant detail, further metabolites, which were much more rarely found as natural products, similarly show interesting biological activities.

摘要

在本综述中，我们将讨论天然存在的间苯二酚内酯，它们由交替链格孢菌素生物合成而来，几乎仅由真菌产生，并对其分离、结构、生物活性、生物合成和全合成进行了探讨。这类化合物目前由127种天然存在的化合物组成，具有非常多样的结构基序。尽管在食品和饲料中作为真菌污染物经常发现并分离出的这类毒素只有少数几种（即交替链格孢菌素及其9-甲基醚、链格孢菌素、脱氢链格孢菌素、交链孢酚和交链孢烯），并且已经进行了详细研究，但作为天然产物更罕见发现的其他代谢产物同样显示出有趣的生物活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/66a2795a0769/Beilstein_J_Org_Chem-20-2171-g043.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/badfb4d91b23/Beilstein_J_Org_Chem-20-2171-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/da550eeb0d77/Beilstein_J_Org_Chem-20-2171-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/96412b4e0cce/Beilstein_J_Org_Chem-20-2171-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/b1efee70aef3/Beilstein_J_Org_Chem-20-2171-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/6de1537c6b5a/Beilstein_J_Org_Chem-20-2171-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/be6e87a9b604/Beilstein_J_Org_Chem-20-2171-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/818fdc76cbae/Beilstein_J_Org_Chem-20-2171-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/363862e4230d/Beilstein_J_Org_Chem-20-2171-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/38d52e3074e8/Beilstein_J_Org_Chem-20-2171-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/9b2f68706cba/Beilstein_J_Org_Chem-20-2171-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/b0fd1158b8d4/Beilstein_J_Org_Chem-20-2171-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/87acb61ef3a5/Beilstein_J_Org_Chem-20-2171-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/7e23687964d2/Beilstein_J_Org_Chem-20-2171-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/a05d60dde6e6/Beilstein_J_Org_Chem-20-2171-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/fff024844292/Beilstein_J_Org_Chem-20-2171-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/e287d5e5e9d8/Beilstein_J_Org_Chem-20-2171-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/b56780bcbf76/Beilstein_J_Org_Chem-20-2171-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/dd362f1c2117/Beilstein_J_Org_Chem-20-2171-g019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/ae97057ae14a/Beilstein_J_Org_Chem-20-2171-g020.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/1db7dbaa2394/Beilstein_J_Org_Chem-20-2171-g030.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/2d6a4130b474/Beilstein_J_Org_Chem-20-2171-g021.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/8570c828e38c/Beilstein_J_Org_Chem-20-2171-g022.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/7a12afefe536/Beilstein_J_Org_Chem-20-2171-g023.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/0e60ad3ca8ad/Beilstein_J_Org_Chem-20-2171-g024.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/ae1ed23847fe/Beilstein_J_Org_Chem-20-2171-g025.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/212534fad549/Beilstein_J_Org_Chem-20-2171-g026.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/9c1ba572dd30/Beilstein_J_Org_Chem-20-2171-g027.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/100280397fc1/Beilstein_J_Org_Chem-20-2171-g028.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/b2a591f11e40/Beilstein_J_Org_Chem-20-2171-g029.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/56870143db16/Beilstein_J_Org_Chem-20-2171-g031.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/14977c7fba3a/Beilstein_J_Org_Chem-20-2171-g032.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/bcccbfbae01b/Beilstein_J_Org_Chem-20-2171-g033.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/45d8c4e95f0f/Beilstein_J_Org_Chem-20-2171-g034.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/7db3003a9b19/Beilstein_J_Org_Chem-20-2171-g035.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/0cc7d1513030/Beilstein_J_Org_Chem-20-2171-g036.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/a8cbaed01e95/Beilstein_J_Org_Chem-20-2171-g037.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/862e394b8ac4/Beilstein_J_Org_Chem-20-2171-g038.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/e0e59dfada1f/Beilstein_J_Org_Chem-20-2171-g039.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/120805eb0bea/Beilstein_J_Org_Chem-20-2171-g040.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/193f39556d74/Beilstein_J_Org_Chem-20-2171-g041.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/d5e30016a22e/Beilstein_J_Org_Chem-20-2171-g042.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/66a2795a0769/Beilstein_J_Org_Chem-20-2171-g043.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/badfb4d91b23/Beilstein_J_Org_Chem-20-2171-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/da550eeb0d77/Beilstein_J_Org_Chem-20-2171-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/96412b4e0cce/Beilstein_J_Org_Chem-20-2171-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/b1efee70aef3/Beilstein_J_Org_Chem-20-2171-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/6de1537c6b5a/Beilstein_J_Org_Chem-20-2171-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/be6e87a9b604/Beilstein_J_Org_Chem-20-2171-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/818fdc76cbae/Beilstein_J_Org_Chem-20-2171-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/363862e4230d/Beilstein_J_Org_Chem-20-2171-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/38d52e3074e8/Beilstein_J_Org_Chem-20-2171-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/9b2f68706cba/Beilstein_J_Org_Chem-20-2171-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/b0fd1158b8d4/Beilstein_J_Org_Chem-20-2171-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/87acb61ef3a5/Beilstein_J_Org_Chem-20-2171-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/7e23687964d2/Beilstein_J_Org_Chem-20-2171-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/a05d60dde6e6/Beilstein_J_Org_Chem-20-2171-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/fff024844292/Beilstein_J_Org_Chem-20-2171-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/e287d5e5e9d8/Beilstein_J_Org_Chem-20-2171-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/b56780bcbf76/Beilstein_J_Org_Chem-20-2171-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/dd362f1c2117/Beilstein_J_Org_Chem-20-2171-g019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/ae97057ae14a/Beilstein_J_Org_Chem-20-2171-g020.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/1db7dbaa2394/Beilstein_J_Org_Chem-20-2171-g030.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/2d6a4130b474/Beilstein_J_Org_Chem-20-2171-g021.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/8570c828e38c/Beilstein_J_Org_Chem-20-2171-g022.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/7a12afefe536/Beilstein_J_Org_Chem-20-2171-g023.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/0e60ad3ca8ad/Beilstein_J_Org_Chem-20-2171-g024.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/ae1ed23847fe/Beilstein_J_Org_Chem-20-2171-g025.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/212534fad549/Beilstein_J_Org_Chem-20-2171-g026.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/9c1ba572dd30/Beilstein_J_Org_Chem-20-2171-g027.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/100280397fc1/Beilstein_J_Org_Chem-20-2171-g028.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/b2a591f11e40/Beilstein_J_Org_Chem-20-2171-g029.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/56870143db16/Beilstein_J_Org_Chem-20-2171-g031.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/14977c7fba3a/Beilstein_J_Org_Chem-20-2171-g032.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/bcccbfbae01b/Beilstein_J_Org_Chem-20-2171-g033.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/45d8c4e95f0f/Beilstein_J_Org_Chem-20-2171-g034.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/7db3003a9b19/Beilstein_J_Org_Chem-20-2171-g035.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/0cc7d1513030/Beilstein_J_Org_Chem-20-2171-g036.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/a8cbaed01e95/Beilstein_J_Org_Chem-20-2171-g037.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/862e394b8ac4/Beilstein_J_Org_Chem-20-2171-g038.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/e0e59dfada1f/Beilstein_J_Org_Chem-20-2171-g039.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/120805eb0bea/Beilstein_J_Org_Chem-20-2171-g040.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/193f39556d74/Beilstein_J_Org_Chem-20-2171-g041.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/d5e30016a22e/Beilstein_J_Org_Chem-20-2171-g042.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0e1/11368053/66a2795a0769/Beilstein_J_Org_Chem-20-2171-g043.jpg

相似文献

1
Natural resorcylic lactones derived from alternariol.源自链格孢酚的天然间苯二酚内酯。
Beilstein J Org Chem. 2024 Aug 30;20:2171-2207. doi: 10.3762/bjoc.20.187. eCollection 2024.
2
Beta resorcylic acid lactones (RALs) from fungi: chemistry, biology, and biosynthesis.真菌中的β-雷琐酸内酯（RALs）：化学、生物学和生物合成。
Arch Pharm Res. 2020 Nov;43(11):1093-1113. doi: 10.1007/s12272-020-01275-6. Epub 2020 Oct 28.
3
Alternaria toxins in South African sunflower seeds: cooperative study.南非葵花籽中的交链孢菌毒素：合作研究。
Mycotoxin Res. 2017 Nov;33(4):309-321. doi: 10.1007/s12550-017-0290-1. Epub 2017 Jul 28.
4
Total synthesis of alternariol.链格孢酚的全合成。
J Org Chem. 2005 Apr 15;70(8):3275-6. doi: 10.1021/jo050075r.
5
Benzenediol lactones: a class of fungal metabolites with diverse structural features and biological activities.苯二酚内酯：一类具有多样结构特征和生物活性的真菌代谢产物。
Eur J Med Chem. 2015 Jun 5;97:747-77. doi: 10.1016/j.ejmech.2014.11.067. Epub 2014 Dec 3.
6
[Alternaria toxins in tomato products marketed in the Russian Federation].[俄罗斯联邦市场上番茄制品中的链格孢毒素]
Vopr Pitan. 2024;93(1):103-111. doi: 10.33029/0042-8833-2024-93-1-103-111. Epub 2024 Jan 19.
7
Toxicity of the Alternaria metabolites alternariol, alternariol methyl ether, altenuene, and tenuazonic acid in the chicken embryo assay.链格孢菌代谢产物交链孢酚、交链孢酚单甲醚、细交链孢菌酮酸和链格孢菌毒素在鸡胚试验中的毒性。
Appl Environ Microbiol. 1983 Dec;46(6):1420-2. doi: 10.1128/aem.46.6.1420-1422.1983.
8
Sulfoglucosides as Novel Modified Forms of the Mycotoxins Alternariol and Alternariol Monomethyl Ether.磺基葡萄糖苷作为霉菌毒素交链孢酚和交链孢酚单甲醚的新型修饰形式。
J Agric Food Chem. 2016 Nov 23;64(46):8892-8901. doi: 10.1021/acs.jafc.6b03120. Epub 2016 Nov 15.
9
Electrochemical simulation of metabolic reactions of the secondary fungal metabolites alternariol and alternariol methyl ether.次生真菌代谢产物链格孢酚和链格孢酚单甲醚代谢反应的电化学模拟
Anal Bioanal Chem. 2016 Apr;408(10):2471-83. doi: 10.1007/s00216-016-9344-z. Epub 2016 Feb 11.
10
Activation of Cellular Antioxidant Defense System by Naturally Occurring Dibenzopyrone Derivatives Confers Neuroprotection against Oxidative Insults.天然二苯并吡喃衍生物激活细胞抗氧化防御系统对抗氧化应激损伤发挥神经保护作用。
ACS Chem Neurosci. 2021 Aug 4;12(15):2798-2809. doi: 10.1021/acschemneuro.1c00023. Epub 2021 Jul 23.

本文引用的文献

1
Graphislactone A, a Fungal Antioxidant Metabolite, Reduces Lipogenesis and Protects against Diet-Induced Hepatic Steatosis in Mice.Graphislactone A，一种真菌抗氧化代谢产物，可减少脂肪生成并预防小鼠饮食诱导的肝脂肪变性。
Int J Mol Sci. 2024 Jan 16;25(2):1096. doi: 10.3390/ijms25021096.
2
Two new constituents from the endophyte of and its anti-neuroinflammatory activity guided by molecular docking.来自[植物名称]内生菌的两种新成分及其分子对接指导下的抗神经炎症活性。 （你提供的原文中“from the endophyte of ”后面缺少具体植物名称）
Nat Prod Res. 2025 Apr;39(8):2140-2150. doi: 10.1080/14786419.2023.2291705. Epub 2023 Dec 11.
3
Secondary metabolites of , isolated from the Cameroonian medicinal plant .
从喀麦隆药用植物中分离得到的……的次生代谢产物。 （原文此处有信息缺失，翻译只能根据现有内容尽量准确呈现）
Beilstein J Org Chem. 2023 Oct 13;19:1555-1561. doi: 10.3762/bjoc.19.112. eCollection 2023.
4
Cytotoxic and antimicrobial mycophenolic acid derivatives from an endophytic fungus Penicillium sp. MNP-HS-2 associated with Macrozamia communis.从与粗齿苏铁相关的内生真菌青霉属菌株MNP-HS-2中分离得到的具有细胞毒性和抗菌活性的霉酚酸衍生物。
Phytochemistry. 2024 Jan;217:113901. doi: 10.1016/j.phytochem.2023.113901. Epub 2023 Oct 24.
5
Benzo[]fluoranthene-Derived Natural Products.苯并[]荧蒽衍生的天然产物。
J Nat Prod. 2023 Jun 23;86(6):1632-1640. doi: 10.1021/acs.jnatprod.3c00078. Epub 2023 Jun 5.
6
Hyposterolactone A, a 3α-Hydroxy Steroidal Lactone from the Deep-Sea-Derived Fungus Hypocrea sp. ZEN14.Hyposterolactone A，一种来源于深海真菌 Hypocrea sp. ZEN14 的 3α-羟基甾体内酯。
Chem Biodivers. 2023 Jul;20(7):e202300753. doi: 10.1002/cbdv.202300753. Epub 2023 Jun 20.
7
Comprehensive review on patulin and toxins in fruit and derived products.水果及其衍生产品中展青霉素和毒素的综合综述。
Front Plant Sci. 2023 Apr 3;14:1139757. doi: 10.3389/fpls.2023.1139757. eCollection 2023.
8
Metabolite Analysis of Mycotoxins by LC-MS/MS and Multiple Tools.LC-MS/MS 及多种工具分析真菌毒素的代谢物
Molecules. 2023 Apr 6;28(7):3258. doi: 10.3390/molecules28073258.
9
An updated overview of anticancer effects of alternariol and its derivatives: underlying molecular mechanisms.交链孢酚及其衍生物抗癌作用的最新综述：潜在分子机制
Front Pharmacol. 2023 Mar 23;14:1099380. doi: 10.3389/fphar.2023.1099380. eCollection 2023.
10
The antifungal metabolites from coculture of and associated with .与……相关的……和……共培养产生的抗真菌代谢产物。 你提供的原文似乎不完整，部分内容缺失，可能会影响更准确的翻译。
Nat Prod Res. 2024 Feb-Mar;38(5):753-758. doi: 10.1080/14786419.2023.2196722. Epub 2023 Apr 6.