ICON Health Economics, 235 Yorkland Boulevard, Toronto, Ontario M2J4Y8, Canada.
Expert Rev Pharmacoecon Outcomes Res. 2015 Feb;15(1):181-9. doi: 10.1586/14737167.2015.965153. Epub 2014 Oct 4.
Uterine fibroids (UF) represent the most common benign uterine tumor in women of reproductive age. Symptoms including heavy, prolonged menstrual bleeding, pelvic pain/pressure, and/or urinary frequency have a substantial impact on women's quality of life and utility values for UF have not been published.
Health state descriptions associated with UF symptoms and treatment side effects were developed based on patient focus groups; validated using expert clinical input; and pilot tested for understandability. Using a web-based questionnaire, 909 community-dwelling, Canadian women were surveyed to assess their perceived value associated with these states.
Utility for uncontrolled bleeding was 0.55 (95% CI: 0.54, 0.57) and the decrement associated with hot flashes was 0.06 (95% CI: -0.07, -0.04). Utility improvement associated with bleeding control was 0.18 (95% CI: 0.17, 0.19) and with smaller fibroid size was 0.03 (95% CI: 0.02, 0.04).
These values illustrate the high utility associated with control of excessive menstrual bleeding.
子宫肌瘤（UF）是生育期妇女最常见的良性子宫肿瘤。包括大量、长时间的月经出血、盆腔疼痛/压迫和/或尿频在内的症状对妇女的生活质量有重大影响，UF 的效用值尚未公布。
根据患者焦点小组制定与 UF 症状和治疗副作用相关的健康状况描述；使用专家临床输入进行验证；并进行理解性预测试。通过基于网络的问卷，对 909 名居住在社区的加拿大妇女进行调查，以评估她们对这些状态的感知价值。
无控制出血的效用为 0.55（95%CI：0.54，0.57），与热潮红相关的减少为 0.06（95%CI：-0.07，-0.04）。出血控制相关的效用改善为 0.18（95%CI：0.17，0.19），与较小的肌瘤大小相关的效用改善为 0.03（95%CI：0.02，0.04）。
这些数值说明了控制过多月经出血相关的高效用。
