Berthonneau J, Tanguy G, Janssens Y, Guichard A, Boyer P, Zorn J R, Cedard L
Laboratoire de Biologie de la Reproduction, Hôpital Jean-Bernard, Poitiers, France.
Hum Reprod. 1989 Aug;4(6):625-8. doi: 10.1093/oxfordjournals.humrep.a136955.
The determination of steroids in saliva provides useful information in the clinical study of various endocrine functions, and salivary progesterone concentration has been widely used for assessing corpus luteum function during the spontaneous menstrual cycle and early pregnancy. However, the determination of oestradiol in saliva (SE2) has previously been found unsatisfactory. SE2 profiles and saliva/plasma E2 ratios were established (during the different periods of the menstrual cycle) by a highly sensitive radioimmunoassay method during normal menstrual cycle. During cycles hyperstimulated for in-vitro fertilization and embryo transfer, the SE2 pattern is similar to the corresponding profile in plasma with a peri-ovulatory oestradiol peak. There is a significant difference between fertile and non-fertile cycles with a higher saliva/plasma ratio in conception cycles.
唾液中类固醇的测定为各种内分泌功能的临床研究提供了有用信息，唾液孕酮浓度已被广泛用于评估自然月经周期和早孕期间的黄体功能。然而，此前发现唾液中雌二醇（SE2）的测定结果并不理想。通过高灵敏度放射免疫测定法在正常月经周期（不同阶段）建立了SE2谱及唾液/血浆E2比值。在体外受精和胚胎移植的超刺激周期中，SE2模式与血浆中相应的模式相似，有一个排卵周围的雌二醇峰值。受孕周期和未受孕周期之间存在显著差异，受孕周期的唾液/血浆比值更高。
