Cedard L, Guichard A, Janssens Y, Tanguy G, Boyer P, Zorn J R
Fertil Steril. 1987 Feb;47(2):278-83. doi: 10.1016/s0015-0282(16)50006-5.
The importance of the luteal function to ensure adequate implantation prompted us to assay salivary estradiol (SE2) and salivary progesterone (SP) concentration serially after embryo transfer by simple and rapid radioimmunoassays to allow a noninvasive easily repeatable approach. SE2, which has fallen 1 day after human chorionic gonadotropin injection, increased after reimplantation (day 3), plateaued during approximately 1 week, and returned to basal levels before menstruation in absence of conception or in chemical pregnancy, whereas it increased steadily in successful pregnancy. SP increased in all the cases, formed a plateau, and returned progressively to basal levels before menstruation, whereas in ongoing pregnancy there was a transitory decline in the midluteal phase followed by a rapid and continuous increase, with a significantly higher ratio day 13/day 10 in successful pregnancy.
黄体功能对于确保充分着床至关重要，这促使我们通过简单快速的放射免疫分析法，在胚胎移植后连续检测唾液雌二醇（SE2）和唾液孕酮（SP）浓度，以实现一种非侵入性且易于重复的方法。人绒毛膜促性腺激素注射后1天下降的SE2，在再次着床后（第3天）升高，在大约1周内保持平稳，在未受孕或化学妊娠时月经前恢复至基础水平，而在成功妊娠时则持续升高。SP在所有病例中均升高，形成一个平台期，并在月经前逐渐恢复至基础水平，而在持续妊娠中，黄体中期有一个短暂下降，随后迅速持续升高，成功妊娠时第13天/第10天的比值显著更高。
