Minabe M, Kodama T, Hori T, Watanabe Y
J Periodontal Res. 1989 May;24(3):178-85. doi: 10.1111/j.1600-0765.1989.tb02003.x.
Collagen membrane preparations have been manufactured with the aim of enhancing wound healing following periodontal surgery. After cross-linking by various processing methods (with ultraviolet radiation or hexamethylenediisocyanate) and to various extents, atelocollagen membranes were applied into dissection sites within palatal gingival tissue. Applied atelocollagen was histopathologically compared with applied lyophilized porcine dermis (LPD) and controls in rats, with regard to the time course of healing. The atelocollagen-applied group showed more satisfactory regeneration of the epithelium and connective tissue in an artificially created gingival defect than did the control group or the LPD-applied group. Epithelial downgrowth along the root surface was significantly suppressed by the use of atelocollagen. In addition, the post-operative inflammatory reaction and foreign body giant cell reaction subsided rapidly after surgery in the atelocollgen-applied group. Our results show that the use of atelocollagen membrane in periodontal wounds should be the method of choice.
制造胶原膜制剂的目的是促进牙周手术后的伤口愈合。通过各种加工方法（紫外线辐射或六亚甲基二异氰酸酯）在不同程度上进行交联后，将去端胶原膜应用于腭部牙龈组织内的解剖部位。在大鼠中，就愈合的时间进程而言，将应用的去端胶原与应用的冻干猪真皮（LPD）和对照组进行了组织病理学比较。与对照组或应用LPD的组相比，应用去端胶原的组在人工造成的牙龈缺损中上皮和结缔组织的再生更令人满意。使用去端胶原可显著抑制上皮沿根面的向下生长。此外，在应用去端胶原的组中，术后炎症反应和异物巨细胞反应在手术后迅速消退。我们的结果表明，在牙周伤口中使用去端胶原膜应是首选方法。
