Grabska-Liberek Iwona, Galus Ryszard, Owczarek Witold, Włodarsk Krzysztof, Zabielski Stanisław, Malejczyk Jacek, Sladowski Dariusz
Samodzielny Publiczny Szpital Kliniczny.
Pol Merkur Lekarski. 2013 Jul;35(205):51-4.
Collagen is the fundamental protein forming the connective tissues matrix, improves the ability of keratinocytes to migrate to sites that require rebuilding of the damaged epidermis, is one of the component of dressings used to accelerate wound healing. Because of the potential risk of the presence of pathogenic prions in bovine collagen, part of collagen dressings is formed on the basis of porcine collagen. Currently, a least of an immunogenic form of collagen is atelocollagen, which is subjected to enzyme-treated collagen, in which the terminal amino acids are removed from the collagen. It is assumed that in the near future atelocollagen will be used also as a carrier for drugs which support the healing processes.
胶原蛋白是构成结缔组织基质的基本蛋白质，可提高角质形成细胞迁移至需要重建受损表皮部位的能力，是用于加速伤口愈合的敷料成分之一。由于牛胶原蛋白中存在致病性朊病毒的潜在风险，部分胶原蛋白敷料是基于猪胶原蛋白制成的。目前，至少一种免疫原性形式的胶原蛋白是脱细胞胶原蛋白，它是经过酶处理的胶原蛋白，其中胶原蛋白的末端氨基酸已被去除。据推测，在不久的将来，脱细胞胶原蛋白也将用作支持愈合过程的药物载体。
