Metabolism. 1965 Jul;14(7):747-58. doi: 10.1016/0026-0495(65)90001-6.
In men in calorie equilibrium, changes in dietary fat produce responses in the serum cholesterol level that, on the average, are predictable from the percentages of total calories provided by saturated (S) and polyunsaturated (P) fatty acid glycerides in the diets concerned. S and P have opposing actions and, in general, Δ Cholesterol (mg./100 ml.) = 2.7ΔS − 1.3ΔP, where Δ refers to the difference between 2 diets. Increasing the number of double bonds beyond 2 in polyunsaturated fatty acids does not result in proportionate increases in serum cholesterol-lowering effect. The mono-enes oleic and erucic acid have little or no effect on the serum cholesterol level when they are exchanged in the diet for equal calories of simple carbohydrate. Changes of fats in the diet produce serum cholesterol responses that are also correlated with the iodine values, or the square-roots of those values, of the fats concerned when the iodine value happens to be highly correlated with 2.7S - 1.3P. When changes in diet fats involve substantial differences in amounts of mono-enes, or of fatty acids containing more than 2 double bonds, the serum cholesterol response has a low or negligible correlation with the iodine value, or its square-root, of the fats.
在热量平衡的男性中，饮食脂肪的变化会导致血清胆固醇水平发生变化，平均而言，这些变化可以根据饮食中饱和（S）和多不饱和（P）脂肪酸甘油酯提供的总卡路里百分比来预测。S 和 P 具有相反的作用，一般来说，Δ胆固醇（mg/100ml）=2.7ΔS-1.3ΔP，其中Δ表示两种饮食之间的差异。在多不饱和脂肪酸中增加双键的数量超过 2 个并不会导致血清胆固醇降低效果成比例增加。当单烯油酸和芥酸在饮食中被等量的简单碳水化合物取代时，它们对血清胆固醇水平几乎没有影响。饮食中脂肪的变化所引起的血清胆固醇反应也与脂肪的碘值或其平方根相关，当碘值与 2.7S-1.3P 高度相关时，这种相关性就会出现。当饮食脂肪的变化涉及单烯或含有超过 2 个双键的脂肪酸的数量发生实质性差异时，血清胆固醇反应与脂肪的碘值或其平方根的相关性较低或可以忽略不计。
