Lin Li, Yin Xiaomao, Hu Xiumei, Wang Qian, Zheng Lei
Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, No.1838 North of Guangzhou Road, Baiyun District, Guangzhou, 510515, People's Republic of China.
Tumour Biol. 2014 Dec;35(12):11695-700. doi: 10.1007/s13277-014-2658-6. Epub 2014 Oct 7.
microRNAs (miRNAs) are evolutionarily conserved small non-coding RNAs, approximately 22 nucleotides (nts) in length, widely found in animals, plants, and viruses. Mature miRNAs control gene expression at a post-transcriptional level through blocking protein translation or inducing mRNA degradation. Many recent studies have shown that hepatitis B virus x protein (HBx), a viral protein with a crucial role in hepatogenesis, is associated with the regulation of miRNAs. This interaction impacts fundamental tumor processes, such as cell proliferation, differentiation, and apoptosis. In this review, we summarized the recent literature on the roles of HBx-regulated miRNAs in the pathogenesis of hepatocellular carcinoma.
微小RNA（miRNA）是一类在进化上保守的小非编码RNA，长度约为22个核苷酸（nt），广泛存在于动物、植物和病毒中。成熟的miRNA通过阻断蛋白质翻译或诱导mRNA降解在转录后水平控制基因表达。最近的许多研究表明，乙型肝炎病毒X蛋白（HBx）是一种在肝脏发生中起关键作用的病毒蛋白，与miRNA的调控有关。这种相互作用影响细胞增殖、分化和凋亡等基本肿瘤过程。在本综述中，我们总结了关于HBx调控的miRNA在肝细胞癌发病机制中作用的最新文献。
