Wang Ziyao, Wu Zhongjun, Huang Ping
National Key Clinical Department, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing 400000, P.R. China.
Oncol Rep. 2017 Aug;38(2):652-664. doi: 10.3892/or.2017.5716. Epub 2017 Jun 13.
MicroRNAs are short RNAs that play a crucial role in all biological processes through post-transcriptional regulation for protein-coding genes and inducing mRNA degradation. Hepatitis B virus infection has been considered as a major risk factor in hepatocellular carcinoma, further research indicates that hepatitis B virus X protein (HBx) is one of the critical links of hepatocarcinogenesis. HBx takes part in hepatocarcinogenesis via regulating transcription, signal transduction, apoptosis, protein degradation and DNA repair. miRNA is the important target gene of HBx, their interaction impacts many tumor processes, such as proliferation, apoptosis, invasion, metastasis, differentiation and adipogenesis. In the present study we reviewed the current state of knowledge of regulation pathway of HBx acting on miRNAs, and focused on the role of their interplay in hepatocarcinogenesis.
微小RNA是一类短RNA，通过对蛋白质编码基因进行转录后调控和诱导信使核糖核酸降解，在所有生物过程中发挥关键作用。乙型肝炎病毒感染一直被认为是肝细胞癌的主要危险因素，进一步研究表明，乙型肝炎病毒X蛋白（HBx）是肝癌发生的关键环节之一。HBx通过调节转录、信号转导、细胞凋亡、蛋白质降解和DNA修复参与肝癌发生。微小RNA是HBx的重要靶基因，它们之间的相互作用影响许多肿瘤进程，如增殖、凋亡、侵袭、转移、分化和脂肪生成。在本研究中，我们综述了HBx作用于微小RNA调控途径的当前知识状态，并重点关注了它们之间的相互作用在肝癌发生中的作用。
