Mirzamoradi Masoumeh, Behnam Marzieh, Jahed Tayebeh, Saleh-Gargari Soraya, Bakhtiyari Mahmood
Department of Perinatology, Infertility and Reproductive Health Research Center (IRHRC), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Infertility and Reproductive Health Research Center (IRHRC), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Taiwan J Obstet Gynecol. 2014 Sep;53(3):309-12. doi: 10.1016/j.tjog.2013.06.014.
Administration of many drugs including magnesium sulfate (MS) has considerable influences on pregnancy outcomes. The present study investigates the effects of MS administration on reaching the active phase of labor in women with premature rupture of membrane (PROM) and subsequent fetal complications.
A double blind, randomized, placebo-controlled trial was performed among primipara women referred to the PROM center in Tehran, Iran between March 2010 and August 2012. Patients were equally allocated into two groups; the intervention group who received MS (n = 46) and the control (placebo) group (n = 46). Both groups received a corticosteroid, 1g oral azithromycin (oral) and 2 g ampicillin (IV) every 6 hours for 48 hours, followed by amoxicillin (500 mg orally 3 times daily) for an additional 5 days. None of the research staff were aware of the treatment allocation of patients in order for blinding purposes.
Administration of MS in intervention group increases this period 2.7 times compared to the control group. In women whose gestational age was <30 weeks, MS administration increased the active phase of labor up to 77%. Administration of magnesium sulfate reduced the risk of respiratory distress syndrome significantly (p = 0 .002), without producing any adverse pregnancy outcomes.
Magnesium sulfate increases delay in reaching the active phase of labor in mothers with PROM, without producing adverse birth outcomes. (Registration ID in IRCT; IRCT2012091810876N1).
包括硫酸镁（MS）在内的多种药物的使用对妊娠结局有相当大的影响。本研究调查了硫酸镁给药对胎膜早破（PROM）女性进入产程活跃期及随后胎儿并发症的影响。
2010年3月至2012年8月期间，在伊朗德黑兰的胎膜早破中心对初产妇进行了一项双盲、随机、安慰剂对照试验。患者被平均分为两组；干预组接受硫酸镁（n = 46），对照组（安慰剂组）（n = 46）。两组均接受皮质类固醇、每6小时口服1g阿奇霉素（口服）和2g氨苄西林（静脉注射），共48小时，随后再口服阿莫西林（500mg，每日3次）5天。为了实现盲法，没有研究人员知道患者的治疗分配情况。
与对照组相比，干预组使用硫酸镁使这一时期增加了2.7倍。在孕周<30周的女性中，使用硫酸镁使产程活跃期增加了77%。硫酸镁的使用显著降低了呼吸窘迫综合征的风险（p = 0.002），且未产生任何不良妊娠结局。
硫酸镁增加了胎膜早破母亲进入产程活跃期的延迟时间，且未产生不良分娩结局。（伊朗临床试验注册中心注册号；IRCT2012091810876N1）
