Lund Anders, Tjølsen Arne, Hole Kjell
Department of Physiology, University of Bergen, BergenNorway.
Pain. 1989 Jul;38(1):65-69. doi: 10.1016/0304-3959(89)90074-2.
Tricyclic antidepressants have shown antinociceptive properties in some, but not in all, animal studies using the tail flick test. Tail flick latency has been found to be strongly negatively correlated to tail skin temperature with its highest correlation found when the temperature is measured close to the heated spot. The selective 5-HT reuptake inhibitor zimelidine, as well as the noradrenaline reuptake inhibitor desipramine, increased tail flick latencies. However, this increase could largely be explained by a concomitant reduction in tail skin temperature. The highest dose of desipramine investigated (25 mg/kg) seemed to possess antinociceptive properties in this test also after correction for the fall in tail skin temperature. Lower doses of desipramine (5 and 15 mg/kg) and zimelidine (5, 20 and 30 mg/kg) were either inactive or their effect on tail flick latency could be explained by the fall in tail skin temperature. The apparent antinociceptive effect of zimelidine in the tail flick test thus seems to be due to an effect on tail skin temperature. Desipramine also seems to have its main effect due to a similar mechanism; however, the highest dose of desipramine used induced significant antinociception.
在一些但并非所有使用甩尾试验的动物研究中，三环类抗抑郁药已显示出抗伤害感受特性。已发现甩尾潜伏期与尾部皮肤温度呈强烈负相关，在靠近加热点测量温度时相关性最高。选择性5-羟色胺再摄取抑制剂齐美利定以及去甲肾上腺素再摄取抑制剂地昔帕明可增加甩尾潜伏期。然而，这种增加很大程度上可由尾部皮肤温度的同时降低来解释。在本试验中，经校正尾部皮肤温度下降后，所研究的地昔帕明最高剂量（25毫克/千克）似乎也具有抗伤害感受特性。较低剂量的地昔帕明（5和15毫克/千克）以及齐美利定（5、20和30毫克/千克）要么无活性，要么它们对甩尾潜伏期的影响可由尾部皮肤温度下降来解释。因此齐美利定在甩尾试验中明显的抗伤害感受作用似乎是由于对尾部皮肤温度产生了影响。地昔帕明似乎也因类似机制产生主要作用；然而，所使用的地昔帕明最高剂量诱导出了显著的抗伤害感受作用。
