Ageel A M
Jpn J Pharmacol. 1986 Jun;41(2):139-45. doi: 10.1254/jjp.41.139.
The effects of the tricyclic antidepressants desipramine HCI and chlorimipramine HCI on buprenorphine HCI antinociceptive activity were studied in mice using the hot-plate and the tail-flick methods. In the hot-plate test, desipramine caused a transient antinociceptive effect at low doses, but it decreased buprenorphine analgesia. Chlorimipramine in this test caused a more sustained antinociceptive effect, especially at relatively higher doses, and it did not significantly change buprenorphine analgesia. In the tail-flick test, desipramine either reduced or increased the tail-flick latency in a dose-specific manner, and chlorimipramine (10 mg/kg) significantly increased the tail-flick latency. Desipramine (1 mg/kg) caused a decrease followed by an increase in buprenorphine analgesia. Desipramine (5 and 10 mg/kg) caused significant increases in buprenorphine analgesia. All doses of chlorimipramine (1, 5 and 10 mg/kg) caused significant increases in buprenorphine analgesia. Thus, depending on the test employed, buprenorphine analgesia was modified differently by these tricyclics. Biochemical data suggested a greater role for brain 5-hydroxytryptamine (5-HT) than noradrenaline in tricyclic analgesia.
采用热板法和甩尾法，在小鼠中研究了盐酸去甲丙咪嗪和盐酸氯米帕明这两种三环类抗抑郁药对盐酸丁丙诺啡镇痛活性的影响。在热板试验中，去甲丙咪嗪在低剂量时引起短暂的镇痛作用，但会降低丁丙诺啡的镇痛效果。氯米帕明在此试验中引起更持久的镇痛作用，尤其是在相对较高剂量时，并且它不会显著改变丁丙诺啡的镇痛效果。在甩尾试验中，去甲丙咪嗪以剂量特异性方式缩短或延长甩尾潜伏期，而氯米帕明（10mg/kg）显著延长甩尾潜伏期。去甲丙咪嗪（1mg/kg）先降低然后增加丁丙诺啡的镇痛效果。去甲丙咪嗪（5mg/kg和10mg/kg）显著增强丁丙诺啡的镇痛效果。所有剂量的氯米帕明（1mg/kg、5mg/kg和10mg/kg）均显著增强丁丙诺啡的镇痛效果。因此，根据所采用的试验，这些三环类药物对丁丙诺啡镇痛效果的影响各不相同。生化数据表明，在三环类药物的镇痛作用中，脑5-羟色胺（5-HT）比去甲肾上腺素起更大作用。
