从中国北京鸭雏中分离出的一种新型呼肠孤病毒的分子特征
Molecular characterization of a novel reovirus isolated from Pekin ducklings in China.
作者信息
Zhu Ying-Qi, Li Chuan-Feng, Bi Zhuang-Li, Chen Zong-Yan, Meng Chun-Chun, Wang Gui-Jun, Ding Chan, Liu Guang-Qing
机构信息
Division of Avian Infectious Diseases, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, 200241, China.
出版信息
Arch Virol. 2015 Jan;160(1):365-9. doi: 10.1007/s00705-014-2241-x. Epub 2014 Oct 7.
The complete genome sequence of a novel duck orthoreovirus, designated DRV strain TH11(DRV-TH11), was determined and characterized. The DRV-TH11 genome is comprised of 23,417 bp and its genome organization is more similar to that of avian orthoreoviruses (ARVs) of chicken origin than other reoviruses. The results of comparative sequence analysis and dendrograms based on the µB- and σC-encoding genes indicated that TH11 may be derived from the reassortment of ARVs and classic Muscovy duck reovirus (MDRV). A possible recombinant event was identified using the SimPlot program, and it occurred in the M2 segment. The results indicated that reassortment and mutation play a role in the evolution of duck reovirus.
确定并表征了一种新型鸭正呼肠孤病毒的全基因组序列，命名为DRV毒株TH11（DRV-TH11）。DRV-TH11基因组由23417个碱基对组成，其基因组结构与鸡源禽正呼肠孤病毒（ARV）比其他呼肠孤病毒更为相似。基于编码µB和σC基因的比较序列分析和系统发育树结果表明，TH11可能源自ARV和经典番鸭呼肠孤病毒（MDRV）的重配。使用SimPlot程序鉴定了一个可能的重组事件，该事件发生在M2片段。结果表明，重配和突变在鸭呼肠孤病毒的进化中起作用。
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