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[系统性红斑狼疮患者免疫发生的紊乱]

[Disturbance of immunogenesis in patients with systemic lupus erythematosus].

作者信息

Adamian N V, Solov'ev S K, Gambarov S S, Alekseev L P

出版信息

Ter Arkh. 1989;61(5):43-5.

PMID:2528836
Abstract

Using a modified model, 16 patients with systemic lupus erythematosus were examined for the activity of nonspecific Con A-induced suppressors with the aid of different test systems. The suppressors of both patients and donors were employed. The proliferation of the test culture lymphocytes appeared to be activated. The immunogenetic abnormalities indicated seem likely to be related to extreme activity of the countersuppressor cells blocking the function of the suppressors, correlating with the clinical picture of the disease.

摘要

采用改良模型,借助不同检测系统对16例系统性红斑狼疮患者的非特异性刀豆蛋白A诱导抑制因子活性进行检测。同时使用患者和供体的抑制因子。试验培养淋巴细胞的增殖似乎被激活。所表明的免疫遗传学异常似乎与阻断抑制因子功能的反抑制细胞的极度活性有关,这与疾病的临床表现相关。

相似文献

1
[Disturbance of immunogenesis in patients with systemic lupus erythematosus].[系统性红斑狼疮患者免疫发生的紊乱]
Ter Arkh. 1989;61(5):43-5.
2
Allogeneic suppression of polyclonal immunoglobulin production in normals and patients with systemic lupus erythematosus.正常人和系统性红斑狼疮患者多克隆免疫球蛋白产生的同种异体抑制。
Clin Exp Immunol. 1980 Oct;42(1):27-32.
3
Suppressor T cells in systemic lupus erythematosus: lack of defective in vitro suppressor cell generation in patients with active disease.系统性红斑狼疮中的抑制性T细胞:活动性疾病患者体外抑制性细胞生成无缺陷
J Clin Lab Immunol. 1982 Jun;8(2):83-90.
4
[Functional activity of nonspecific T-lymphocyte suppressors in health persons and in systemic lupus erythematosus patients].[健康人和系统性红斑狼疮患者中非特异性T淋巴细胞抑制因子的功能活性]
Vrach Delo. 1980 Jan(1):88-90.
5
Deficiencies in suppressor T cell activity seen in patients with active systemic lupus erythematosus are due to the dilution of normally functioning suppressor T cells by nonsuppressor T cells.在活动性系统性红斑狼疮患者中观察到的抑制性T细胞活性缺陷,是由于正常发挥功能的抑制性T细胞被非抑制性T细胞稀释所致。
J Immunol. 1986 Dec 15;137(12):3809-13.
6
Con A suppressor cell assay: a further characterization.刀豆球蛋白A抑制细胞试验:进一步的特性研究
J Clin Lab Immunol. 1983 Mar;10(3):159-63.
7
Depressed primary in vitro antibody response in untreated systemic lupus erythematosus. T helper cell defect and lack of defective suppressor cell function.未经治疗的系统性红斑狼疮患者体外抗体反应低下。辅助性T细胞缺陷且抑制性细胞功能无缺陷。
J Clin Invest. 1980 Jul;66(1):141-8. doi: 10.1172/JCI109827.
8
Role of stimulated neutrophils from patients with systemic lupus erythematosus in disturbed immunoreactivity, with special reference to increased oxygen intermediates generated by the neutrophils.
J Clin Lab Immunol. 1984 May;14(1):35-43.
9
Depressed effector activity of OKT4+ and OKT8+ T cell subsets in lectin-dependent cell-mediated cytotoxicity to HEP-2 cells in patients with systemic lupus erythematosus.系统性红斑狼疮患者中,OKT4 +和OKT8 + T细胞亚群在对HEP - 2细胞的凝集素依赖性细胞介导的细胞毒性中的效应器活性降低。
J Clin Lab Immunol. 1984 Oct;15(2):95-100.
10
[T-suppressor functional activity in systemic lupus erythematosus and chronic glomerulonephritis].[系统性红斑狼疮和慢性肾小球肾炎中抑制性T细胞的功能活性]
Ter Arkh. 1982;54(7):29-32.