inhibitor reduces the proliferation and migration in osteosarcoma MG-63 cells.

As the most common malignant primary bone tumor in childhood, osteosarcoma (OS) maintains a high recurrence, despite the significant improvements in the overall survival rate of high-grade OS patients during the recent decades. Therefore, a novel therapy strategy is required for OS treatment. Recently, various microRNAs (miRNAs or miRs) have been confirmed as deregulated in OS, and the dysregulation in OS has been discovered by the microarray analysis. In the present study, the regulation of on the OS cell proliferation, migration and invasion on the MG-63 cells was explored . The mimics were found to promote cell proliferation, colony formation, migration and invasion significantly, compared to the control miRNA. An inhibitor was also used to evaluate whether served as a therapeutic target for OS. The results demonstrated that the inhibitor significantly reduced the proliferation, colony formation, migration and invasion of the MG-63 OS cells. Thus, the study confirmed the oncogenic regulation on the OS progression of , which could serve as a therapeutic target with an inhibitor.