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脂肪填充后背阔肌皮瓣受乳腺导管癌侵犯

Latissimus dorsi flap invasion by ductal breast carcinoma after lipofilling.

作者信息

Alharbi Muhannad, Garrido Ignacio, Vaysse Charlotte, Chavoin Jean Pierre, Grolleau Jean Louis, Chaput Benoit

机构信息

Department of Plastic and Reconstructive Surgery, Faculty of Medicine, University of Toulouse Rangueil, Toulouse, France; and Department of Surgery and Gynecology, Faculty of Medicine, University of Toulouse Rangueil, Toulouse, France.

出版信息

Plast Reconstr Surg Glob Open. 2013 Dec 6;1(8):e68. doi: 10.1097/GOX.0000000000000012. eCollection 2013 Nov.

DOI:10.1097/GOX.0000000000000012
PMID:25289263
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4186293/
Abstract

Autologous fat grafting is commonly performed in reconstructive breast surgery but also increasingly in breast augmentation surgery. On the international level, we are witnessing an important increased confidence for this procedure. Nevertheless, it continues to raise questions on the risks of cancer. A 66-year-old patient benefited from a lipofilling to improve a latissimus dorsi flap breast reconstruction, 7 years after initial cancer management. Two years later, constant pain in the flap leads to reoperation. The flap showed a major retraction with histologically massive infiltration of the muscle by an undifferentiated carcinoma of breast origin. The tumor cells were displayed directly in contact with lipofilling inside the muscle. Without establishing any causal link between these 2 events, this case raises the question once more of the risks of breast cancer and encourages us to continue being careful.

摘要

自体脂肪移植术在乳房重建手术中很常见,在隆乳手术中也越来越常用。在国际上,我们看到人们对该手术的信心显著增强。然而,它仍引发了关于癌症风险的问题。一名66岁的患者在最初的癌症治疗7年后,接受了脂肪填充术以改善背阔肌肌皮瓣乳房重建效果。两年后,皮瓣持续疼痛导致再次手术。皮瓣出现严重挛缩,组织学检查显示肌肉被乳腺来源的未分化癌大量浸润。肿瘤细胞直接与肌肉内的脂肪填充物接触。虽然未确定这两个事件之间存在任何因果关系,但该病例再次引发了乳腺癌风险的问题,并促使我们继续保持谨慎。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b3b/4186293/1ce698fb925c/gox-1-e68-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b3b/4186293/4878024510be/gox-1-e68-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b3b/4186293/0ede46294d71/gox-1-e68-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b3b/4186293/1ce698fb925c/gox-1-e68-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b3b/4186293/4878024510be/gox-1-e68-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b3b/4186293/0ede46294d71/gox-1-e68-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b3b/4186293/1ce698fb925c/gox-1-e68-g003.jpg

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本文引用的文献

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Recurrence of an invasive ductal breast carcinoma 4 months after autologous fat grafting.自体脂肪移植4个月后浸润性导管乳腺癌复发。
Plast Reconstr Surg. 2013 Jan;131(1):123e-124e. doi: 10.1097/PRS.0b013e318272a1f6.
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The white adipose tissue used in lipotransfer procedures is a rich reservoir of CD34+ progenitors able to promote cancer progression.脂肪组织是富含 CD34+祖细胞的丰富储备库,能够促进癌症的进展。
Cancer Res. 2012 Jan 1;72(1):325-34. doi: 10.1158/0008-5472.CAN-11-1739. Epub 2011 Nov 3.
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Cancer Res. 2011 Apr 1;71(7):2455-65. doi: 10.1158/0008-5472.CAN-10-3323.
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Plast Reconstr Surg. 2011 Mar;127(3):1289-1299. doi: 10.1097/PRS.0b013e318205f38f.
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Oncologic risks of autologous fat grafting to the breast.自体脂肪移植乳房的肿瘤学风险。
Aesthet Surg J. 2011 Jan;31(1):68-75. doi: 10.1177/1090820X10390922.
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[The adipose tissue transfer in the mammary parenchyma (part II): Review of the literature on the carcinologic risks].
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[The adipose tissue transfer in the mammary parenchyma (part I): Review of the literature on modifications of the radiological images].
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