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复杂小儿鼻部病变的成功重建:使用真皮再生模板改善治疗效果

Successful reconstruction of complex pediatric nasal lesions: improving outcomes using dermal regenerative templates.

作者信息

Grunwaldt Lorelei J, Adetayo Oluwaseun A, MacIsaac Zoe M, Losee Joseph E, Kumar Anand R

机构信息

Division of Pediatric Plastic and Reconstructive Surgery, University of Pittsburgh, Cleft/Craniofacial Center, Children's Hospital of Pittsburgh, Pittsburgh, Pa.

出版信息

Plast Reconstr Surg Glob Open. 2014 Mar 6;2(2):e107. doi: 10.1097/GOX.0000000000000033. eCollection 2014 Feb.

Abstract

BACKGROUND

Dermal regenerate templates are currently widely used in both adult and pediatric burn reconstruction. Despite this, the safety and efficacy of regenerate templates combined with full-thickness skin grafts for the reconstruction of pediatric facial defects traditionally treated with local flaps is not widely published. The aim of this study is to report the safety and efficacy of pediatric nasal defect reconstruction using regenerative templates/full-thickness skin grafts.

METHODS

A retrospective review of one institution's experience with pediatric nasal defects treated with regenerative templates was performed. All patients (n = 4) were treated with a multistage protocol. Two reviewers independently assigned Visual Analogue Cosmetic Scale (VACS) scores: 1 surgeon and 1 nonsurgical researcher not involved in patient care. Standardized photographs (anteroposterior, oblique, lateral, and worm's eye view) were assigned VACS scores according to a 100-point scale: "abhorrent," 0-24; "poor," 25-49; "moderate," 50-74; and "excellent," 75-100. Statistical analysis was performed using Mann-Whitney U and Wilcoxon paired signed-rank tests.

RESULTS

Four patients (2 boys and 2 girls, average age 6.8 yr) who met the inclusion criteria were identified. A total of 5 nasal lesions (2 spitz nevi, 1 vascular lesion, and 2 congenital nevi) were removed. The preoperative VACS score was 45.2 (range, 5-70), compared with 84.5 (range, 45-100) postoperatively (P <0.000). There was no significant difference between raters (preoperative, P = 0.346; postoperative, P = 0.678).

CONCLUSIONS

The reconstruction of complex pediatric nasal lesions using dermal regenerative templates and full-thickness postauricular skin grafts is safe and effective, and associated with low morbidity and significant improvement in VACS scores.

摘要

背景

真皮再生模板目前广泛应用于成人和小儿烧伤重建。尽管如此,将再生模板与全厚皮片联合用于传统上采用局部皮瓣治疗的小儿面部缺损重建的安全性和有效性尚未广泛发表。本研究的目的是报告使用再生模板/全厚皮片进行小儿鼻缺损重建的安全性和有效性。

方法

对一家机构治疗小儿鼻缺损使用再生模板的经验进行回顾性分析。所有患者(n = 4)均采用多阶段方案治疗。两名评估者独立分配视觉模拟美容量表(VACS)评分:1名外科医生和1名未参与患者护理的非外科研究人员。标准化照片(前后位、斜位、侧位和虫眼视图)根据100分制分配VACS评分:“令人厌恶”,0 - 24分;“差”,25 - 49分;“中等”,50 - 74分;“优秀”,75 - 100分。使用曼 - 惠特尼U检验和威尔科克森配对符号秩检验进行统计分析。

结果

确定了4名符合纳入标准的患者(2名男孩和2名女孩,平均年龄6.8岁)。共切除5处鼻部病变(2处雀斑样痣、1处血管病变和2处先天性痣)。术前VACS评分为45.2(范围5 - 70),术后为84.5(范围45 - 100)(P <0.000)。评估者之间无显著差异(术前,P = 0.346;术后,P = 0.678)。

结论

使用真皮再生模板和耳后全厚皮片重建复杂小儿鼻部病变是安全有效的,且发病率低,VACS评分有显著改善。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8171/4173827/de8c65661122/gox-2-e107-g001.jpg

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