Paediatric Burn Center, Plastic and Reconstructive Surgery, Department of Surgery, University Children's Hospital Zurich, Steinwiesstr. 75, CH-8032 Zurich, Switzerland.
J Plast Reconstr Aesthet Surg. 2010 Apr;63(4):610-5. doi: 10.1016/j.bjps.2009.01.050. Epub 2009 Mar 14.
The optimal surgical treatment of giant congenital melanocytic naevi remains a considerable challenge in reconstructive surgery. None of the currently available techniques is universally applicable. The goal of this pilot study was to test Integra Artificial Skin (Integra) in the surgical treatment of giant congenital melanocytic naevi.
Between May 2000 and March 2004, Integra was used in 12 children (n=12; aged seven months to 11 years, mean 3.8 years). Giant congenital melanocytic naevi covered 1-12% of the total body surface area (mean 4.2%) located over the trunk in 50%, and over face and extremities in 25% each.
In eight children, Integra implantation was primarily successful; in four patients a partial or complete removal and re-implantation was necessary due to complications. The final take rate of Integra ranged from 95-100%, except for one patient with a take rate of 30% (mean 93%). Second stage split-thickness skin grafting yielded take rates from 95-100% (mean 98%). Functional and cosmetic outcome was rated excellent in 58%, good in 25% and fair in 17% (follow-up six months to four years, mean 2.2 years).
These results suggest that Integra is a new and valid method to successfully treat giant congenital melanocytic naevi in early childhood in a definitive manner and with high-quality results.
巨大先天性黑色素痣的最佳手术治疗仍然是重建手术中的一个重大挑战。目前尚无一种技术可普遍适用。本初步研究的目的是测试 Integra 人工皮（ Integra ）在巨大先天性黑色素痣的手术治疗中的应用。
2000 年 5 月至 2004 年 3 月，Integra 用于 12 例儿童（ n = 12 ；年龄 7 个月至 11 岁，平均 3.8 岁）。巨大先天性黑色素痣覆盖 1-12%的总体表面积（平均 4.2%），位于躯干 50%，面部和四肢各 25%。
在 8 例儿童中，Integra 植入术主要成功；4 例因并发症需要部分或完全切除和再植入。Integra 的最终成活率为 95-100%，除 1 例成活率为 30%（平均 93%）外。二期分层皮片移植成活率为 95-100%（平均 98%）。功能和美容效果评定为优 58%，良 25%，可 17%（随访 6 个月至 4 年，平均 2.2 年）。
这些结果表明，Integra 是一种新的有效方法，可成功地以高质量的结果，在幼儿期以确定性方式治疗巨大先天性黑色素痣。
