Dörner T, Gagelmann M, Feller S, Herbst F, Forssmann W G
Institut für Anatomie und Zellbiologie III, Universität Heidelberg, FRG.
Biochem Biophys Res Commun. 1989 Sep 15;163(2):830-5. doi: 10.1016/0006-291x(89)92297-3.
Urodilatin (CDD-/ANP-95-126), a new peptide hormone from human urine, is comprised of the same amino acid sequence as cardiodilatin (CDD-99-126/alpha-hANP) except for N-terminal extention by four amino acid residues. The presence of the recognition sequence Arg101-Arg-Ser-Ser104 for the cyclic AMP-dependent protein kinase enables rapid phosphorylation in the Ser104-position. Phosphorylation of urodilatin is associated with decreased vasorelaxant potency, while dephosphorylation of "phospho-urodilatin" by acidic phosphatase completely restores bioactivity.
尿舒张素（CDD-/ANP-95-126）是一种源自人尿液的新型肽类激素，其氨基酸序列与心钠素（CDD-99-126/α-hANP）相同，只是在N端多了四个氨基酸残基。环磷酸腺苷依赖性蛋白激酶的识别序列Arg101-Arg-Ser-Ser104的存在使得尿舒张素能够在Ser104位快速磷酸化。尿舒张素的磷酸化与血管舒张效力降低有关，而酸性磷酸酶对“磷酸化尿舒张素”的去磷酸化作用可完全恢复其生物活性。
