Adams D O, Nathan C F
Departments of Pathology and Microbiology and Immunology, Duke University, Durham, NC 27710, USA.
Department of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA.
Immunol Today. 1983 Jun;4(6):166-70. doi: 10.1016/0167-5699(83)90005-1.
Macrophages kill tumor cells with and without the aid of antibody and evidence suggests that secreted cytotoxic substances are at work in each system. Here Dolph Adams and Carl Nathan discuss the likely involvement in both pathways of several such substances including cytolytic protease and hydrogen peroxide.
巨噬细胞在有或没有抗体协助的情况下杀死肿瘤细胞，且有证据表明分泌的细胞毒性物质在每个系统中都发挥着作用。在此，多尔夫·亚当斯和卡尔·内森讨论了几种此类物质（包括溶细胞蛋白酶和过氧化氢）可能在这两种途径中所起的作用。
