Herman J, Kew M C, Rabson A R
Cancer Immunol Immunother. 1984;16(3):182-5. doi: 10.1007/BF00205426.
Interleukin-1 (IL-1) production by monocytes of patients with various forms of malignant disease was measured after activating the cells with either lipopolysaccharide or malignant K562 cells. Monocytes from all the patients with large tumour masses, including 10 patients with hepatocellular carcinoma, produced considerably less IL-1 than controls or patients with small tumour burdens. After treating control or patient monocytes with human leucocyte interferon for 1 h prior to activation, IL-1 production was markedly improved. Depressed IL-1 production is, therefore, a further aberration in mononuclear function observed in patients with cancer.
在用脂多糖或恶性K562细胞激活细胞后,测定了患有各种形式恶性疾病患者的单核细胞白细胞介素-1(IL-1)产生情况。所有患有大肿瘤块的患者,包括10例肝细胞癌患者的单核细胞产生的IL-1比对照组或肿瘤负荷小的患者少得多。在用人类白细胞干扰素在激活前1小时处理对照组或患者单核细胞后,IL-1产生显著改善。因此,IL-1产生受抑制是癌症患者中观察到的单核细胞功能的又一异常。