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恶性疾病患者单核细胞白细胞介素-1产生缺陷。干扰素可增加白细胞介素-1的产生。

Defective interleukin-1 production by monocytes from patients with malignant disease. Interferon increases IL-1 production.

作者信息

Herman J, Kew M C, Rabson A R

出版信息

Cancer Immunol Immunother. 1984;16(3):182-5. doi: 10.1007/BF00205426.

DOI:10.1007/BF00205426
PMID:6608404
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11039280/
Abstract

Interleukin-1 (IL-1) production by monocytes of patients with various forms of malignant disease was measured after activating the cells with either lipopolysaccharide or malignant K562 cells. Monocytes from all the patients with large tumour masses, including 10 patients with hepatocellular carcinoma, produced considerably less IL-1 than controls or patients with small tumour burdens. After treating control or patient monocytes with human leucocyte interferon for 1 h prior to activation, IL-1 production was markedly improved. Depressed IL-1 production is, therefore, a further aberration in mononuclear function observed in patients with cancer.

摘要

在用脂多糖或恶性K562细胞激活细胞后，测定了患有各种形式恶性疾病患者的单核细胞白细胞介素-1（IL-1）产生情况。所有患有大肿瘤块的患者，包括10例肝细胞癌患者的单核细胞产生的IL-1比对照组或肿瘤负荷小的患者少得多。在用人类白细胞干扰素在激活前1小时处理对照组或患者单核细胞后，IL-1产生显著改善。因此，IL-1产生受抑制是癌症患者中观察到的单核细胞功能的又一异常。

相似文献

1
Defective interleukin-1 production by monocytes from patients with malignant disease. Interferon increases IL-1 production.恶性疾病患者单核细胞白细胞介素-1产生缺陷。干扰素可增加白细胞介素-1的产生。
Cancer Immunol Immunother. 1984;16(3):182-5. doi: 10.1007/BF00205426.
2
Defective interleukin-1 production by natural killer cells of patients with cancer.癌症患者自然杀伤细胞产生白细胞介素-1存在缺陷。
Cancer Immunol Immunother. 1985;19(2):148-53. doi: 10.1007/BF00199724.
3
Regulation of interferon production by human monocytes: requirements for priming for lipopolysaccharide-induced production.人单核细胞对干扰素产生的调节：脂多糖诱导产生的启动要求。
J Leukoc Biol. 1991 Aug;50(2):176-81. doi: 10.1002/jlb.50.2.176.
4
Interferons as macrophage-activating factors. III. Preferential effects of interferon-gamma on the interleukin 1 secretory potential of fresh or aged human monocytes.干扰素作为巨噬细胞激活因子。III. 干扰素-γ对新鲜或老化人单核细胞白细胞介素1分泌潜能的优先作用。
J Immunol. 1985 Apr;134(4):2444-8.
5
Cytokine regulation of human monocyte interleukin-1 (IL-1) production in vitro. Enhancement of IL-1 production by interferon (IFN) gamma, tumour necrosis factor-alpha, IL-2 and IL-1, and inhibition by IFN-alpha.细胞因子对人单核细胞白细胞介素-1（IL-1）体外产生的调节作用。γ干扰素、肿瘤坏死因子-α、IL-2和IL-1可增强IL-1的产生，而α干扰素则起抑制作用。
Clin Exp Immunol. 1990 Jun;80(3):435-43. doi: 10.1111/j.1365-2249.1990.tb03306.x.
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Interleukin 1 production by human monocytes induced in culture with K562 cells.用K562细胞在培养中诱导人单核细胞产生白细胞介素1 。
Res Exp Med (Berl). 1991;191(3):201-8. doi: 10.1007/BF02576675.
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Braz J Med Biol Res. 1989;22(10):1259-70.
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Defective interleukin-1 production of monocytes in patients with bladder cancer.膀胱癌患者单核细胞白细胞介素-1产生缺陷。
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Modulation of in vitro monocyte cytokine responses to Leishmania donovani. Interferon-gamma prevents parasite-induced inhibition of interleukin 1 production and primes monocytes to respond to Leishmania by producing both tumor necrosis factor-alpha and interleukin 1.体外单核细胞对杜氏利什曼原虫细胞因子反应的调节。γ干扰素可防止寄生虫诱导的白细胞介素1产生的抑制，并使单核细胞通过产生肿瘤坏死因子-α和白细胞介素1对利什曼原虫作出反应。
J Clin Invest. 1990 Jun;85(6):1914-24. doi: 10.1172/JCI114654.

引用本文的文献

1
An update on human interleukin-1: from molecular biology to clinical relevance.人类白细胞介素-1的最新进展：从分子生物学到临床相关性
J Clin Immunol. 1985 Sep;5(5):287-97. doi: 10.1007/BF00918247.
2
Effects of human interleukin-1 on natural killer cell activity: is fever a host defense mechanism for tumor killing?人白细胞介素-1对自然杀伤细胞活性的影响：发热是一种肿瘤杀伤的宿主防御机制吗？
Yale J Biol Med. 1986 Mar-Apr;59(2):97-106.
3
Defective interleukin-1 production in a familial monocyte disorder with a combined abnormality of mobility and phagocytosis-killing.一种伴有迁移和吞噬杀伤联合异常的家族性单核细胞疾病中白细胞介素-1产生缺陷。
Clin Exp Immunol. 1988 Sep;73(3):500-4.
4
Enhanced production of gamma-interferon by therapy with parenteral OK-432 and alpha-interferon in patients with head and neck cancer.对头颈部癌患者采用胃肠外注射OK-432和α-干扰素治疗可增强γ-干扰素的产生。
Arch Otorhinolaryngol. 1986;243(5):281-7. doi: 10.1007/BF00460202.
5
The effect of RU 41.740 (Biostim) on the production of interleukin-1 by monocytes and enriched large granular lymphocytes in normals and patients with hepatocellular carcinoma.RU 41.740（生物刺激素）对正常人和肝细胞癌患者单核细胞及富集大颗粒淋巴细胞产生白细胞介素-1的影响。
Cancer Immunol Immunother. 1986;21(1):26-30. doi: 10.1007/BF00199373.
6
Defective interleukin-1 production by natural killer cells of patients with cancer.癌症患者自然杀伤细胞产生白细胞介素-1存在缺陷。
Cancer Immunol Immunother. 1985;19(2):148-53. doi: 10.1007/BF00199724.
7
Effects of L2C leukemia on macrophage-mediated responses.L2C白血病对巨噬细胞介导反应的影响。
Cancer Immunol Immunother. 1987;25(2):75-80. doi: 10.1007/BF00199944.
8
Tumour necrosis factor-alpha enhances the cytolytic and cytostatic capacity of interleukin-2 activated killer cells.肿瘤坏死因子-α增强白细胞介素-2激活的杀伤细胞的细胞溶解和细胞抑制能力。
Br J Cancer. 1989 Apr;59(4):573-7. doi: 10.1038/bjc.1989.116.
9
Expression of the genes of interferons and other cytokines in normal and diseased tissues of man.人正常组织和病变组织中干扰素及其他细胞因子基因的表达
Experientia. 1989 Jun 15;45(6):526-35. doi: 10.1007/BF01990502.
10
The altered expression of MHC-class II determinants on monocytes of cancer patients.癌症患者单核细胞上MHC-II类决定簇的表达改变。
Cancer Immunol Immunother. 1988;27(2):171-6. doi: 10.1007/BF00200023.

本文引用的文献

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Interleukin 1 is more than an interleukin.白细胞介素1不仅仅是一种白细胞介素。
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Recombinant mouse gamma interferon induces the priming step in macrophage activation for tumor cell killing.重组小鼠γ干扰素在巨噬细胞激活以杀伤肿瘤细胞的过程中诱导启动步骤。
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Interferons as macrophage-activating factors. II. Enhanced secretion of interleukin 1 by lipopolysaccharide-stimulated human monocytes.干扰素作为巨噬细胞激活因子。II. 脂多糖刺激的人单核细胞白细胞介素1分泌增强。
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Interferon-induced enhancement of macrophage Fc receptor expression: beta-interferon treatment of C3H/HeJ macrophages results in increased numbers and density of Fc receptors.干扰素诱导巨噬细胞Fc受体表达增强：用β-干扰素处理C3H/HeJ巨噬细胞可导致Fc受体数量增加和密度升高。
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