Synthesis of phosphoramidates: a facile approach based on the C-N bond formation via Ir-catalyzed direct C-H amidation.

A new synthetic route to phosphoramidates by intermolecular C-H amidation is presented. Substrates with assorted directing groups were activated by an iridium-based catalyst system and reacted with a number of phosphoryl azides, executing efficient phosphoramidate synthesis via C-N bond formations.