Wang Lianhui, Yang Zi, Yang Mengqi, Tian Miaodou, Kuai Changsheng, Cui Xiuling
Engineering Research Center of Molecular Medicine of Ministry of Education, Key Laboratory of Fujian Molecular Medicine, Key Laboratory of Xiamen Marine and Gene Drugs, School of Biomedical Sciences, Huaqiao University, Xiamen, Fujian, 361021, P. R. China.
Chem Asian J. 2017 Oct 5;12(19):2634-2643. doi: 10.1002/asia.201701028. Epub 2017 Sep 7.
A highly efficient and regioselective Ir -catalyzed C-H amidation of 2-phenoxypyridines has been developed by using sulfonyl azides as an amino source. The amidated products were provided in good-to-excellent yields with broad functional-group tolerance. Furthermore, the 2-pyridyl moiety in the amidated products could be readily removed, thus offering an efficient route to synthetically useful ortho-hydroxyanilnes, which are important building blocks in organic synthesis.
通过使用磺酰叠氮化物作为氨基源，开发了一种高效且区域选择性的铱催化的2-苯氧基吡啶的C-H酰胺化反应。酰胺化产物的产率良好至优异，具有广泛的官能团耐受性。此外，酰胺化产物中的2-吡啶基部分可以很容易地除去，从而提供了一条合成有用的邻羟基苯胺的有效途径，邻羟基苯胺是有机合成中的重要结构单元。
