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放射性标记抗体在肿瘤定位中的限制因素。

Limiting factors in the localization of tumours with radiolabelled antibodies.

作者信息

Bradwell A R, Fairweather D S, Dykes P W, Keeling A, Vaughan A, Taylor J

机构信息

Immuno Diagnostic Research Laboratory, Department of Immunology, The Medical School, University of Birmingham. B15 2TJ, UK.

Department of Geriatric Medicine, University Hospital of South Manchester, Nell Lane, Manchester, M20 8LR, UK.

出版信息

Immunol Today. 1985 May;6(5):163-70. doi: 10.1016/0167-5699(85)90146-X.

Abstract

The use of radiolabelled antibodies in tumour detection is being intensely studied. Here A. R. Bradwell and colleagues discuss the use of radioimmunolocation and conclude that although many different tumour types can be localized, results at present are no better than with otherscanning techniques. Dramatic improvements will depend upon afuller understanding of tumour cell biology and the optimization of all the parameters that contribute to successful scans.

摘要

放射性标记抗体在肿瘤检测中的应用正在进行深入研究。在此,A. R. 布拉德韦尔及其同事讨论了放射免疫定位的应用,并得出结论:尽管许多不同类型的肿瘤都可以定位,但目前的结果并不比其他扫描技术更好。显著的改进将取决于对肿瘤细胞生物学的更全面理解以及对所有有助于成功扫描的参数的优化。

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