心房利钠肽（ANP）对犬脑动脉的作用：神经源性舒张并非由ANP释放介导的证据。
Action of atrial natriuretic peptide (ANP) on dog cerebral arteries: evidence that neurogenic relaxation is not mediated by release of ANP.
作者信息
Okamura T, Inoue S, Toda N
机构信息
Department of Pharmacology, Shiga University of Medical Sciences, Ohtsu, Japan.
出版信息
Br J Pharmacol. 1989 Aug;97(4):1258-64. doi: 10.1111/j.1476-5381.1989.tb12587.x.
Abstract
- Atrial natriuretic peptide (ANP) (10(-9) to 10(-8) M) produced a concentration-related relaxation in helical strips of dog cerebral arteries partially contracted with prostaglandin F2 alpha. The relaxation was not affected by treatment with ouabain, quinidine, oxyhaemoglobin, methylene blue, or removal of endothelium. 2. Relaxations induced by nicotine or transmural electrical stimulation were not reduced in arteries in which tachyphylaxis to ANP had developed. 3. In arteries exposed to Ca2+-free media under severe hypoxia, contractions due to prostaglandin F2 alpha and Ca2+ were attenuated by treatment with ANP, whereas the reoxygenation-induced contraction was unaffected. 4. The results suggest that ANP does not mediate neurogenic relaxation of dog cerebral arteries. The ANP-induced relaxation is not associated with activation of the sodium pump but is due to an inhibitory action on the release and influx of Ca2+, probably as a result of stimulation of guanylate cyclase.
摘要
- 心房利钠肽（ANP）（10⁻⁹至10⁻⁸M）可使部分被前列腺素F2α预收缩的犬脑动脉螺旋条产生浓度依赖性舒张。该舒张不受哇巴因、奎尼丁、氧合血红蛋白、亚甲蓝处理或去除内皮的影响。2. 在对ANP产生快速耐受的动脉中，尼古丁或跨壁电刺激诱导的舒张未减弱。3. 在严重缺氧条件下暴露于无钙培养基的动脉中，前列腺素F2α和Ca²⁺引起的收缩可被ANP处理减弱，而复氧诱导的收缩不受影响。4. 结果表明，ANP不介导犬脑动脉的神经源性舒张。ANP诱导的舒张与钠泵的激活无关，而是由于对Ca²⁺释放和内流的抑制作用，可能是刺激鸟苷酸环化酶的结果。
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Action of atrial natriuretic peptide (ANP) on dog cerebral arteries: evidence that neurogenic relaxation is not mediated by release of ANP.心房利钠肽（ANP）对犬脑动脉的作用：神经源性舒张并非由ANP释放介导的证据。
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本文引用的文献
1
A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats.大鼠静脉注射心房肌提取物后出现快速且强效的利钠反应。
Life Sci. 1981 Jan 5;28(1):89-94. doi: 10.1016/0024-3205(81)90370-2.
2
Hemolysate-induced contraction in smooth muscle cells of the guinea pig basilar artery.
Stroke. 1984 May-Jun;15(3):503-10. doi: 10.1161/01.str.15.3.503.
3
Vasodilator profile of synthetic atrial natriuretic factor.合成心房利钠因子的血管舒张特性
Eur J Pharmacol. 1984 Jun 15;102(1):169-73. doi: 10.1016/0014-2999(84)90353-4.
4
Purification and complete amino acid sequence of alpha-human atrial natriuretic polypeptide (alpha-hANP).α-人心房利钠多肽（α-hANP）的纯化及完整氨基酸序列
Biochem Biophys Res Commun. 1984 Jan 13;118(1):131-9. doi: 10.1016/0006-291x(84)91077-5.
5
Atrial natriuretic factor elicits an endothelium-independent relaxation and activates particulate guanylate cyclase in vascular smooth muscle.心钠素可引起不依赖内皮的舒张反应，并激活血管平滑肌中的颗粒型鸟苷酸环化酶。
Proc Natl Acad Sci U S A. 1984 Dec;81(23):7661-4. doi: 10.1073/pnas.81.23.7661.
6
Atrial natriuretic factor selectively activates particulate guanylate cyclase and elevates cyclic GMP in rat tissues.心钠素可选择性激活大鼠组织中的颗粒性鸟苷酸环化酶并提高环磷酸鸟苷水平。
J Biol Chem. 1984 Dec 10;259(23):14332-4.
7
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