心钠素可引起不依赖内皮的舒张反应，并激活血管平滑肌中的颗粒型鸟苷酸环化酶。
Atrial natriuretic factor elicits an endothelium-independent relaxation and activates particulate guanylate cyclase in vascular smooth muscle.
作者信息
Winquist R J, Faison E P, Waldman S A, Schwartz K, Murad F, Rapoport R M
出版信息
Proc Natl Acad Sci U S A. 1984 Dec;81(23):7661-4. doi: 10.1073/pnas.81.23.7661.
Abstract
A 26 amino acid synthetic peptide fragment of atrial natriuretic factor (ANF) relaxed isolated rabbit aortic segments in which the endothelium was either intact or functionally destroyed. The relaxations were temporally associated with increases in levels of cGMP with no change in the levels of cAMP. The ANF-induced increases in cGMP were also observed in aortic segments pretreated with calcium-free buffer or the cGMP phosphodiesterase inhibitor M&B 22,948. Qualitatively similar results were obtained for sodium nitroprusside. ANF selectively activated particulate guanylate cyclase, having no effect on the soluble form of the enzyme. Thus, the direct (endothelium-independent) vasodilator effect of ANF may be mediated via increased tissue levels of cGMP. ANF appears to increase vascular cGMP levels by activation of particulate guanylate cyclase.
摘要
心房利钠因子（ANF）的一个26个氨基酸的合成肽片段可使内皮完整或功能受损的离体兔主动脉段舒张。这种舒张在时间上与cGMP水平升高相关，而cAMP水平无变化。在用无钙缓冲液或cGMP磷酸二酯酶抑制剂M&B 22,948预处理的主动脉段中也观察到ANF诱导的cGMP升高。硝普钠也得到了定性相似的结果。ANF选择性激活颗粒型鸟苷酸环化酶，对该酶的可溶性形式无影响。因此，ANF的直接（不依赖内皮）血管舒张作用可能是通过增加组织cGMP水平介导的。ANF似乎通过激活颗粒型鸟苷酸环化酶来增加血管cGMP水平。
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本文引用的文献
1
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Life Sci. 1981 Jan 5;28(1):89-94. doi: 10.1016/0024-3205(81)90370-2.
2
Bioactive cardiac substances: potent vasorelaxant activity in mammalian atria.生物活性心脏物质：在哺乳动物心房中具有强大的血管舒张活性。
Science. 1983 Jul 1;221(4605):71-3. doi: 10.1126/science.6857267.
3
Vasodilator profile of synthetic atrial natriuretic factor.合成心房利钠因子的血管舒张特性
Eur J Pharmacol. 1984 Jun 15;102(1):169-73. doi: 10.1016/0014-2999(84)90353-4.
4
Isolation and sequence determination of peptide components of atrial natriuretic factor.心房利钠因子肽成分的分离与序列测定
Biochem Biophys Res Commun. 1984 May 16;120(3):981-8. doi: 10.1016/s0006-291x(84)80203-x.
5
Purification and sequence analysis of bioactive atrial peptides (atriopeptins).生物活性心房肽（心钠素）的纯化与序列分析
Science. 1984 Jan 6;223(4631):67-9. doi: 10.1126/science.6419347.
6
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Res Commun Chem Pathol Pharmacol. 1983 Sep;41(3):369-81.
7
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Circ Res. 1983 Nov;53(5):557-73. doi: 10.1161/01.res.53.5.557.
8
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9
Amino acid sequence of homologous rat atrial peptides: natriuretic activity of native and synthetic forms.同源大鼠心房肽的氨基酸序列：天然形式和合成形式的利钠活性。
Proc Natl Acad Sci U S A. 1984 May;81(9):2640-4. doi: 10.1073/pnas.81.9.2640.
10
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Biochem Biophys Res Commun. 1983 Dec 28;117(3):859-65. doi: 10.1016/0006-291x(83)91675-3.
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