前列腺素F2α在浸泡于过量钾溶液中的离体犬脑动脉、冠状动脉和肠系膜动脉中诱导的收缩。
Prostaglandin F2 alpha-induced contraction in isolated dog cerebral, coronary and mesenteric arteries soaked in excess potassium.
作者信息
Toda N, Onoue H
机构信息
Department of Pharmacology, Shiga University of Medical Sciences, Ohtsu, Japan.
出版信息
Jpn J Pharmacol. 1988 Jun;47(2):204-7. doi: 10.1254/jjp.47.204.
Concentration-response curve for prostaglandin (PG) F2 alpha in helical strips of dog cerebral, coronary and mesenteric arteries were compared in control media and in those in which all the NaCl was replaced with isomolar KCl. Contractile responses to PGF2 alpha in concentrations up to 2 x 10(-6) M in cerebral arteries, to 10(-5) M in coronary arteries and to 5 x 10(-7) M in mesenteric arteries were not attenuated by excess K+. Contractions caused by PGF2 alpha, at least at these concentrations or lower, may not be associated with membrane depolarization.
在对照培养基以及所有氯化钠被等摩尔氯化钾替代的培养基中，比较了前列腺素（PG）F2α 在犬脑动脉、冠状动脉和肠系膜动脉螺旋条中的浓度 - 反应曲线。在脑动脉中，高达2×10⁻⁶ M浓度的PGF2α引起的收缩反应，在冠状动脉中为10⁻⁵ M，在肠系膜动脉中为5×10⁻⁷ M，均未因过量钾离子而减弱。PGF2α引起的收缩，至少在这些浓度或更低浓度时，可能与膜去极化无关。
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