Klaus G G, Humphrey J H
National Institute for Medical Research, Mill Hill, London NW7, UK.
Royal Postgraduate Medical School, Ducane Road, London W12, UK.
Immunol Today. 1986 Jun;7(6):163-5. doi: 10.1016/0167-5699(86)90165-9.
There is considerable evidence that, in vivo, C3 is required for the induction and maintenance of memory cells of the B-cell lineage. Recent data from in-vitro systems indicate that ligation of C3 receptors on B cells can activate these cells, and that appropriately presented C3 split products can act as B-cell growth factors. Here, Gerry Klaus and John Humphrey propose that in vivo these growth-promoting effects of C3 may operate within the microenvironment of germinal centres, where B cells encounter antigen-antibody-C3 complexes on the surfaces of follicular dendritic cells.
有大量证据表明，在体内，C3是B细胞系记忆细胞诱导和维持所必需的。来自体外系统的最新数据表明，B细胞上C3受体的连接可激活这些细胞，且适当呈现的C3裂解产物可作为B细胞生长因子。在此，格里·克劳斯和约翰·汉弗莱提出，在体内，C3的这些促生长作用可能在生发中心的微环境中发挥作用，在生发中心B细胞会遇到滤泡树突状细胞表面的抗原-抗体-C3复合物。
