滤泡树突状细胞真的毫无用处吗？

Are follicular dendritic cells really good for nothing?

作者信息

Kosco-Vilbois Marie H

机构信息

NovImmune S.A., 64 Avenue de la Roseraie, CH-1205 Geneva, Switzerland.

出版信息

Nat Rev Immunol. 2003 Sep;3(9):764-9. doi: 10.1038/nri1179.

DOI:10.1038/nri1179

PMID:12949500

Abstract

Follicular dendritic cells (FDCs), which reside in the primary B-cell follicles and germinal centres of lymphoid tissues, can sequester antigen in the form of immune complexes and are thought to be pivotal to the germinal-centre reaction and the maintenance of immunological memory. But, many recent studies question the importance of FDCs and their bound immune complexes in B-cell responses. This article asks whether we can truly rule out a requirement for these cells in host defence.

摘要

滤泡树突状细胞（FDCs）存在于淋巴组织的初级B细胞滤泡和生发中心，能够以免疫复合物的形式隔离抗原，被认为对生发中心反应和免疫记忆的维持至关重要。但是，最近许多研究对FDCs及其结合的免疫复合物在B细胞反应中的重要性提出了质疑。本文探讨我们是否真的可以排除这些细胞在宿主防御中的必要性。