Grouard G, Durand I, Filgueira L, Banchereau J, Liu Y J
Schering-Plough, Laboratory for Immunological Research, Dardilly, France.
Nature. 1996 Nov 28;384(6607):364-7. doi: 10.1038/384364a0.
The B cells within the germinal centres of lymphoid organs undergo affinity maturation of their antigen receptors, a critical event for antibody memory. Follicular dendritic cells within the germinal centres retain immune complexes that select the developing B cells for which they have a higher affinity. We have now identified a subset of CD4+ CD11c+ CD3- dendritic cells in the germinal centres. These are strong antigen-presenting cells for T cells, but do not co-stimulate CD40-activated B cells. These dendritic cells probably stimulate germinal centre T cells and aid the complicated processes that are required for the generation of memory B cells.
淋巴器官生发中心内的B细胞会经历其抗原受体的亲和力成熟过程，这是抗体记忆的关键事件。生发中心内的滤泡树突状细胞保留免疫复合物，这些复合物会选择与其具有更高亲和力的正在发育的B细胞。我们现在已经在生发中心鉴定出了一个CD4+ CD11c+ CD3-树突状细胞亚群。这些细胞是T细胞的强大抗原呈递细胞，但不会共刺激CD40激活的B细胞。这些树突状细胞可能刺激生发中心T细胞，并有助于记忆B细胞产生所需的复杂过程。
