衰老对大鼠纹状体中含D2受体神经元浓度的影响。
Effect of aging on concentrations of D2-receptor-containing neurons in the rat striatum.
作者信息
Han Z, Kuyatt B L, Kochman K A, DeSouza E B, Roth G S
机构信息
Molecular Physiology and Genetics Section, National Institute on Aging, Francis Scott Key Medical Center, Baltimore, MD 21224.
出版信息
Brain Res. 1989 Oct 2;498(2):299-307. doi: 10.1016/0006-8993(89)91108-6.
Striatal D2 dopamine receptor concentrations were shown to decrease 30-35% during the lifespan of Wistar rats as assessed both radiochemically and autoradiographically. Binding densities and degree of age-change varied within the striatum; the latter ranging from 17 to 44% in 4 different regions. Overall neuronal loss during aging was 19%, and also varied considerably within the different striatal regions. Thus, it appears that neuronal loss may account for up to roughly half of the striatal D2 receptor loss during aging.
通过放射化学和放射自显影评估显示，在Wistar大鼠的生命周期中，纹状体D2多巴胺受体浓度降低了30%-35%。纹状体内的结合密度和年龄变化程度各不相同；在4个不同区域中，后者的变化范围为17%至44%。衰老过程中总体神经元损失为19%，在不同的纹状体区域中也有很大差异。因此，似乎神经元损失可能占衰老过程中纹状体D2受体损失的大约一半。
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