Wang D W, Yu S, Wu T G
Zhonghua Xin Xue Guan Bing Za Zhi. 1989 Apr;17(2):83-5, 126.
Intratube thrombus and in vitro intraarterial thrombus and isolated normal pig aortic wall were radiated by excimer laser with wavelength of 308 nm and pulse width of 20 ns. The single pulse energy and the numbers of pulses were varied at the constant beam size and pulse frequency and the results were studied by micrometer measurement and histological examination. The results show: (1) excimer laser can effectively ablate thrombus. With constant total energy (at the range from 10 to 50 J), the depth of vaporized thrombus was nonlinearly proportional to the single pulse energy. But with constant single pulse energy (at the range from 10-100m J), the depth of vaporized thrombus was in linear proportion to the numbers of pulses; (2) if coaxial position of laser beam with blood vessel was maintained, thrombus can be effectively vaporized without arterial wall damage; (3) the incision produced by excimer laser has microscopically precise edges: there is no evidence of thermal injury and adjacent tissue is unaffected. Our conclusion is that excimer laser can be used safely and effectively in angioplasty. It may be mainly by photochemical effect that excimer laser ablates organic tissue.
用波长为308nm、脉宽为20ns的准分子激光照射管内血栓、体外动脉内血栓及离体正常猪主动脉壁。在光束尺寸和脉冲频率恒定的情况下，改变单脉冲能量和脉冲数，并通过千分尺测量和组织学检查研究结果。结果表明：（1）准分子激光能有效消融血栓。在总能量恒定（10至50J范围内）时，血栓汽化深度与单脉冲能量呈非线性比例关系。但在单脉冲能量恒定（10 - 100mJ范围内）时，血栓汽化深度与脉冲数呈线性比例关系；（2）若保持激光束与血管的同轴位置，可有效汽化血栓而不损伤动脉壁；（3）准分子激光产生的切口在显微镜下边缘精确：无热损伤迹象，邻近组织未受影响。我们的结论是，准分子激光可安全有效地用于血管成形术。准分子激光消融有机组织可能主要是通过光化学效应。
