Wendling D, Didier J M, Seilles E
Department of Rheumatology, Centre Hospitalier Universitaire, Faculté de Médecine et Pharmacie, Besançon, France.
Clin Rheumatol. 1996 Nov;15(6):590-3. doi: 10.1007/BF02238549.
Humoral mucosal immunity may be implicated in pathophysiology of ankylosing spondylitis (AS). The aim of the study was to evaluate serum levels of IgA, IgM and secretory IgA (sIgA), secretory IgM (sIgM) as well as free secretory component (FSC) in patients with AS compared to controls and rheumatoid arthritis (RA) patients. Levels of sIgA, sIgM and FSC were measured with a specific ELISA in 37 AS patients, 45 controls and 27 RA. The results were as follows: Serum levels of IgA were higher in AS vs controls and in RA vs controls (p = 0.01). Levels of sIgA were higher in AS vs controls (p = 0.01), but higher in RA vs AS (p = 10(-4)). There was no difference of sIgM in AS vs controls, FSC levels were higher in AS vs controls, and higher in AS patients with elevated CRP. In view of elevated FSC, this increase of sIgA in AS may have been due to excessive production of mucosal IgA after bacterial stimulation according to the current hypothesis of the disease.
体液黏膜免疫可能与强直性脊柱炎（AS）的病理生理有关。本研究的目的是评估AS患者与对照组及类风湿关节炎（RA）患者相比，血清中IgA、IgM和分泌型IgA（sIgA）、分泌型IgM（sIgM）以及游离分泌成分（FSC）的水平。采用特异性酶联免疫吸附测定法（ELISA）检测了37例AS患者、45例对照者和27例RA患者的sIgA、sIgM和FSC水平。结果如下：AS患者与对照组相比以及RA患者与对照组相比，血清IgA水平均较高（p = 0.01）。AS患者与对照组相比，sIgA水平较高（p = 0.01），但RA患者与AS患者相比更高（p = 10⁻⁴）。AS患者与对照组相比，sIgM无差异，FSC水平在AS患者与对照组相比时较高，在CRP升高的AS患者中更高。鉴于FSC升高，根据目前的疾病假说，AS患者中sIgA的这种增加可能是由于细菌刺激后黏膜IgA过度产生所致。
