天然自身抗体可能预防自身免疫性疾病。
Natural autoantibodies might prevent autoimmune disease.
作者信息
Cohen I R, Cooke A
机构信息
Department of Cell Biology, The Weizmann Institute of Science, PO Box 26, Rehovot, 76100, Israel.
Department of Immunology, The Middlesex Hospital, London, W1 P 9PG, UK.
出版信息
Immunol Today. 1986 Dec;7(12):363-4. doi: 10.1016/0167-5699(86)90026-5.
PMID:25291331
Abstract
Autoantibodies are common in healthy individuals and appear not to be harmful. It is not clear how they arise nor what their function is. Here Irun Cohen and Anne Cooke propose that these natural autoantibodies bind to self or self-mimicking epitopes and so prevent the initiation of a damaging auto immune response.
摘要
自身抗体在健康个体中很常见，且似乎并无危害。目前尚不清楚它们是如何产生的，其功能又是什么。在此，伊伦·科恩和安妮·库克提出，这些天然自身抗体与自身或自身模拟表位结合，从而防止有害的自身免疫反应的启动。
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