The avidin-biotin complex in immunology.

The tenacious interaction between the vitamin biotin and theglycoprotein avidin has been applied in many immunological systems for the isolation, localization and visualization of various antigens as well as drug delivery, lymphocyte stimulation and immunoassays. These are discussed hereby Meir Wilchek and Edward Bayer, who emphasize that with the increased refinement of affinity systems, the avidin-biotin complex will undoubtedly enable improved detectability and determination of minute amounts of antigens.