Du Jin-Ze, Dong Yu-Ling, Wan Guo-Xing, Tao Lin, Lu Li-Xia, Li Feng, Pang Li-Juan, Jia Wei
Department of Pathology, Shihezi University School of Medicine, Shihezi, China E-mail :
Asian Pac J Cancer Prev. 2014;15(18):7941-5. doi: 10.7314/apjcp.2014.15.18.7941.
Catechol-O-methyltransferase (COMT) is involved in estrogen metabolism and is vital to estrogen-induced carcinogenesis, including that of ovarian cancer. Although many recent epidemiologic studies have investigated associations between the COMT rs4680 polymorphism and ovarian cancer risk, the results remain inconclusive. We therefore performed a meta-analysis to derive a more precise estimate of associations. Systematic searches of the PubMed, Embase, Web of Science, Cochrane Library, Wanfang, China National Knowledge Infrastructure, and Chinese Biomedicine databases were undertaken to retrieve eligible studies. Odds ratios (ORs) with their corresponding 95% confidence intervals (CIs) were pooled to assess the strength of the association. In total, 8 case-control studies involving 1,293 cases and 2,647 controls were included in the meta-analysis. Overall, the results showed no evidence of significant association between the COMT rs4680 polymorphism and ovarian cancer risk in any of the assessed genetic models. Subgroup analyses by ethnicity also did not reveal any significant association in any genetic model (p>0.05). In conclusion, our findings suggest that the COMT rs4680 polymorphism may not contribute to the risk of ovarian cancer.
儿茶酚-O-甲基转移酶（COMT）参与雌激素代谢，对雌激素诱导的致癌作用至关重要，包括卵巢癌的致癌作用。尽管最近许多流行病学研究调查了COMT rs4680多态性与卵巢癌风险之间的关联，但其结果仍无定论。因此，我们进行了一项荟萃分析，以得出更精确的关联估计。我们对PubMed、Embase、Web of Science、Cochrane图书馆、万方、中国知网和中国生物医学数据库进行了系统检索，以获取符合条件的研究。汇总比值比（OR）及其相应的95%置信区间（CI），以评估关联强度。荟萃分析共纳入8项病例对照研究，涉及1293例病例和2647例对照。总体而言，结果显示在任何评估的遗传模型中，均无证据表明COMT rs4680多态性与卵巢癌风险之间存在显著关联。按种族进行的亚组分析在任何遗传模型中也未发现任何显著关联（p>0.05）。总之，我们的研究结果表明，COMT rs4680多态性可能与卵巢癌风险无关。
