Pu Qianghong, Yu Chao
Institute of Life Science, Chongqing Medical University, Box 174#, No. 1 Yixueyuan Road, Yuzhong District, Chongqing, 400016, People's Republic of China.
Glycoconj J. 2014 Dec;31(9):605-11. doi: 10.1007/s10719-014-9560-8. Epub 2014 Oct 8.
Cardiovascular diseases arising from atherosclerosis are currently the leading cause of mortality worldwide. Leukocyte recruitment is a key step for the successful initiation of atherosclerosis and occurs predominantly in the inflamed endothelium. Leukocyte recruitment is mediated by a group of adhesive molecules and chemokine receptors, which are often glycosylated protein. Recent studies demonstrated that post-translational glycosylation by glycosyltransferases is necessary for adhesive molecules and chemokine receptors activities. Several glycosyltransferases, such as α2,3-sialyltransferases IV, α1,3-fucosyltransferases IV and VII, core 2 β1,6-N-acetylglucosaminyltransferase-I, are considered to participate in the synthesis of glycosylation for adhesive molecules and chemokine receptors, and the initiation of atherosclerotic lesions. In this review, we will discuss new data concerning the roles of different glycosyltransferases in atherogenesis. The knowledge of glycosyltransferases in atherogenesis offers the opportunity to develop novel therapeutic strategies.
由动脉粥样硬化引起的心血管疾病是目前全球主要的死亡原因。白细胞募集是动脉粥样硬化成功起始的关键步骤，主要发生在炎症内皮中。白细胞募集由一组粘附分子和趋化因子受体介导，这些分子通常是糖基化蛋白。最近的研究表明，糖基转移酶进行的翻译后糖基化对于粘附分子和趋化因子受体的活性是必需的。几种糖基转移酶，如α2,3-唾液酸转移酶IV、α1,3-岩藻糖转移酶IV和VII、核心2β1,6-N-乙酰葡糖胺基转移酶-I，被认为参与了粘附分子和趋化因子受体糖基化的合成以及动脉粥样硬化病变的起始。在这篇综述中，我们将讨论关于不同糖基转移酶在动脉粥样硬化发生中作用的新数据。糖基转移酶在动脉粥样硬化发生中的知识为开发新的治疗策略提供了机会。
