State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road, Shanghai 201203, People's Republic of China.
Org Lett. 2014 Oct 17;16(20):5478-81. doi: 10.1021/ol5027552. Epub 2014 Oct 8.
Three limonoids, trichiconin A (1) possessing a new carbon skeleton of a rearranged A,B-ring system and trichiconins B (2) and C (3) featuring an unprecedented A,B,D-seco skeleton, were isolated from the twigs of Trichilia connaroides. The carbon scaffold of trichiconin A is designated as trichiconane. Their structures with absolute stereochemistry were determined by spectroscopic data, X-ray crystallography, and CD analysis. Compounds 2 and 3 showed modest anti-HIV activities.
从三蕊木的嫩枝中分离得到了三种新的柠檬苦素类化合物，分别为：1，具有重排的 A、B-环系统的新碳骨架的三尖杉宁 A；2，和 3，具有前所未有的 A、B、D-去环骨架的三尖杉宁 B 和 C。三尖杉宁 A 的碳骨架被指定为三尖杉烷。它们的结构和绝对立体化学通过光谱数据、X 射线晶体学和 CD 分析确定。化合物 2 和 3 表现出适度的抗 HIV 活性。
